Ritalin and Malic acid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ritalin (methylphenidate hydrochloride) and Malic acid (alpha hydroxy acids). Common drug interactions include osteoarthritis among females.

The phase IV clinical study analyzes what interactions people have when they take Ritalin and Malic acid. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Ritalin?

Ritalin has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 29,427 Ritalin users. Check the latest studies of Ritalin.

What is Malic acid?

Malic acid has active ingredients of alpha hydroxy acids. It is often used in fibromyalgia. eHealthMe is studying from 246 Malic acid users. Check the latest studies of Malic acid.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

14 people who take Ritalin and Malic acid together, and have interactions are studied.

Ritalin and Malic acid drug interactions.

What are the common drug interactions of Ritalin and Malic Acid, by gender? *:

female:

Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Complex regional pain syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet))
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Autonomic nervous system imbalance (autonomic nervous system is of net equal emphasis)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Ear infection
Suicidal ideation
Initial insomnia (feeling of inadequate or poor-quality sleep)
Weight increased
Anaemia (lack of blood)

male:

n/a

What are the common drug interactions of Ritalin and Malic Acid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Cardiac disorder
Hepatic mass
Postural orthostatic tachycardia syndrome (abnormal increase in heart rate on becoming upright)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Autonomic nervous system imbalance (autonomic nervous system is of net equal emphasis)

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 14 people, 100.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 42.86%

* Approximation only. Some reports may have incomplete information.

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