Ritalin and Pradaxa drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ritalin (methylphenidate hydrochloride) and Pradaxa (dabigatran etexilate mesylate). Common drug interactions include pain among females and pleural effusion among males.

The phase IV clinical study analyzes what interactions people have when they take Ritalin and Pradaxa. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Ritalin?

Ritalin has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 29,427 Ritalin users. Check the latest studies of Ritalin.

What is Pradaxa?

Pradaxa has active ingredients of dabigatran etexilate mesylate. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 86,906 Pradaxa users. Check the latest studies of Pradaxa.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

27 people who take Ritalin and Pradaxa together, and have interactions are studied.

What are the common drug interactions of Ritalin and Pradaxa, by gender? *:

female:

Pain
Dizziness
Coagulopathy (blood's ability to clot is impaired)
Haematoma (collection of blood outside the blood vessels)
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Thrombosis (formation of a blood clot inside a blood vessel)
Hypertension (high blood pressure)
Hypoaesthesia oral (reduced sense of touch or sensation in mouth)
Paraesthesia oral (sensation of tingling, tickling, prickling, pricking, or burning of a person's oral with no apparent long-term physical effect)

male:

Pleural effusion (water on the lungs)
Aphasia (damage to the parts of the brain that control language)
Drug ineffective
Back pain
Burning sensation
Counterfeit drug administered
Haemorrhage (bleeding)
Nausea (feeling of having an urge to vomit)
Pain
Renal failure (kidney dysfunction)

What are the common drug interactions of Ritalin and Pradaxa, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Anaemia (lack of blood)
Dizziness
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Haemorrhage (bleeding)
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Tremor (trembling or shaking movements in one or more parts of your body)

20-29:

n/a

30-39:

Pain
Coagulopathy (blood's ability to clot is impaired)
Headache (pain in head)
Thrombosis (formation of a blood clot inside a blood vessel)
Blood pressure increased
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Hypokalaemia (low potassium)
Muscle strain (an injury to a muscle in which the muscle fibres tear)
Patellofemoral pain syndrome (pain in the front of the knee)
Vitamin d deficiency

40-49:

Aphonia (inability to produce voice)
Cough
Dyspnoea (difficult or laboured respiration)
Gait disturbance
Heart rate increased
Lung disorder (lung disease)
Memory impairment
Palpitations (feelings or sensations that your heart is pounding or racing)
Speech disorder
Tremor (trembling or shaking movements in one or more parts of your body)

50-59:

Back pain
Burning sensation
Cough
Diarrhoea
Fall
Fatigue (feeling of tiredness)
Musculoskeletal disorder (disease of the body's muscles, joints, tendons, ligaments and nerves)
Nausea (feeling of having an urge to vomit)
Pain
Sinusitis (inflammation of sinus)

60+:

Pleural effusion (water on the lungs)
Aphasia (damage to the parts of the brain that control language)
Haematoma (collection of blood outside the blood vessels)
Dizziness
Nausea (feeling of having an urge to vomit)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Coagulopathy (blood's ability to clot is impaired)
Haemorrhage intracranial (bleeding within the skull)
Hypertension (high blood pressure)
Hypoaesthesia oral (reduced sense of touch or sensation in mouth)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 22.22%
Pain: 4 people, 14.81%
High Blood Pressure: 4 people, 14.81%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 11.11%
Bipolar Disorder (mood disorder): 3 people, 11.11%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 11.11%
Nervousness: 3 people, 11.11%
Stress And Anxiety: 3 people, 11.11%
Hypersensitivity: 3 people, 11.11%
Wheezing (a high-pitched whistling sound made while you breath): 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

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