Rituxan and Tranexamic acid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rituxan (rituximab) and Tranexamic acid (tranexamic acid). Common drug interactions include impaired gastric emptying among females and platelet count decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Rituxan and Tranexamic acid. It is created by eHealthMe based on reports of 73 people who take the same drugs from the FDA, and is updated regularly.

What is Rituxan?

Rituxan has active ingredients of rituximab. It is often used in rheumatoid arthritis. eHealthMe is studying from 64,792 Rituxan users. Check the latest studies of Rituxan.

What is Tranexamic acid?

Tranexamic acid has active ingredients of tranexamic acid. It is often used in heavy or prolong menstrual bleeding. eHealthMe is studying from 8,687 Tranexamic acid users. Check the latest studies of Tranexamic acid.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

73 people who take Rituxan and Tranexamic acid together, and have interactions are studied.

Rituxan and Tranexamic acid drug interactions.

What are the common drug interactions of Rituxan and Tranexamic Acid, by gender? *:

female:

Impaired gastric emptying
Oropharyngeal blistering (blister of oropharynx)
Platelet count decreased
Red blood cell count decreased
Renal failure acute (rapid kidney dysfunction)
Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
Bacteraemia (presence of bacteria in the blood)
Epstein-barr virus infection
Arthralgia (joint pain)
Thrombocytopenia (decrease of platelets in blood)

male:

Platelet count decreased
Immune thrombocytopenic purpura (destruction of blood platelets due to the presence of antiplatelet auto antibodies)
Myelodysplastic syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged)
Neutropenia (an abnormally low number of neutrophils)
Pyrexia (fever)
White blood cell count decreased
Febrile neutropenia (fever with reduced white blood cells)
Abdominal discomfort
Abdominal tenderness
Cataract (clouding of the lens inside the eye)

What are the common drug interactions of Rituxan and Tranexamic Acid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
Bacteraemia (presence of bacteria in the blood)
Epstein-barr virus infection
Aplasia (defective development or congenital absence of an organ or tissue)
Epistaxis (bleed from the nose)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Thrombocytopenia (decrease of platelets in blood)
Mucosal inflammation (infection of mucous membrane)

10-19:

Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)
Hypertension (high blood pressure)
Lung disorder (lung disease)
Renal failure (kidney dysfunction)
Respiratory failure (inadequate gas exchange by the respiratory system)
Retinopathy (acute damage to the retina of the eye)
Thrombocytopenia (decrease of platelets in blood)
Thrombotic microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury)
Renal failure acute (rapid kidney dysfunction)
Blood lactate dehydrogenase increased

20-29:

Influenza
Sinusitis (inflammation of sinus)
Urticaria (rash of round, red welts on the skin that itch intensely)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Infusion related reaction
Angioedema (rapid swelling of the dermis)

30-39:

Haemoglobin decreased
Rash erythematous (redness of the skin)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Rectal haemorrhage (bleeding from anus)
Vaginal haemorrhage (vaginal bleeding)
Arthralgia (joint pain)
Melaena (the passage of black, tarry stools)
Purpura (purplish discoloration of the skin)
Haemorrhage (bleeding)
Death

40-49:

Blood beta-d-glucan increased
Cystitis haemorrhagic (blood in the urine and painful voiding)
Haematuria (presence of blood in urine)
Haemoglobin decreased
Hydronephrosis (water inside the kidney)
Nasopharyngitis (inflammation of the nasopharynx)
Neutropenia (an abnormally low number of neutrophils)
Oedema (fluid collection in tissue)
Oedema peripheral (superficial swelling)
Oral infection

50-59:

Immune thrombocytopenic purpura (destruction of blood platelets due to the presence of antiplatelet auto antibodies)
Anaemia (lack of blood)
Arthralgia (joint pain)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Drug intolerance (drug sensitivity)
Fibroma (tumours that are composed of fibrous or connective tissue)
Gastric disorder (disease of stomach)
Infusion related reaction
Uterine disorder
Vulvovaginal discomfort

60+:

Platelet count decreased
Constipation
Febrile neutropenia (fever with reduced white blood cells)
Abdominal discomfort
Abdominal tenderness
Diarrhoea
Energy increased
Feeling jittery
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Headache (pain in head)

What are the existing conditions these people have? *

Lymphoma (cancer that begins in immune system cells): 18 people, 24.66%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 15 people, 20.55%
Idiopathic Thrombocytopenic Purpura (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting): 9 people, 12.33%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 8 people, 10.96%

* Approximation only. Some reports may have incomplete information.

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