Rizatriptan benzoate and Provigil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rizatriptan benzoate (rizatriptan benzoate) and Provigil (modafinil). Common drug interactions include body mass index increased among females.

The phase IV clinical study analyzes what interactions people have when they take Rizatriptan benzoate and Provigil. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Rizatriptan benzoate?

Rizatriptan benzoate has active ingredients of rizatriptan benzoate. It is often used in migraine. eHealthMe is studying from 1,886 Rizatriptan benzoate users. Check the latest studies of Rizatriptan benzoate.

What is Provigil?

Provigil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 25,230 Provigil users. Check the latest studies of Provigil.



On Jul, 14, 2026

26 people who take Rizatriptan benzoate and Provigil together, and have interactions are studied.

Rizatriptan benzoate and Provigil drug interactions.

What are the common drug interactions of Rizatriptan Benzoate and Provigil, by gender? *:

female:

  1. Body mass index increased
  2. Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
  3. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  4. Bedridden
  5. Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
  6. Chills (felling of cold)
  7. Cystitis (inflammation of the wall of the bladder)
  8. Depression
  9. Fall
  10. Joint injury

male:

n/a

What are the common drug interactions of Rizatriptan Benzoate and Provigil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  2. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  3. Abdominal pain upper
  4. Asthenia (weakness)
  5. Back pain
  6. Cardiac aneurysm (a condition that can occur after a myocardial infarction due to the inadequate resistance of the new scar tissue to the systolic pressure)
  7. Flushing (the warm, red condition of human skin)
  8. Insomnia (sleeplessness)
  9. Lymphocyte count decreased
  10. Memory impairment

40-49:

  1. Pain
  2. Osteoarthritis (a joint disease caused by cartilage loss in a joint)
  3. Osteonecrosis (death of bone)
  4. Bedridden
  5. Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
  6. Cystitis (inflammation of the wall of the bladder)
  7. Dizziness
  8. Fall
  9. Hip arthroplasty
  10. Joint injury

50-59:

  1. Pyrexia (fever)
  2. Vomiting
  3. Body mass index increased
  4. Alopecia (absence of hair from areas of the body)
  5. Chills (felling of cold)
  6. Diarrhoea
  7. Flushing (the warm, red condition of human skin)
  8. Nausea (feeling of having an urge to vomit)

60+:

  1. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  2. Depression
  3. Dizziness
  4. Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))

What are the existing conditions these people have? *

  1. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 14 people, 53.85%
  2. Pain: 7 people, 26.92%
  3. Headache (pain in head): 6 people, 23.08%
  4. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 19.23%
  5. Wheezing (a high-pitched whistling sound made while you breath): 4 people, 15.38%
  6. Rashes (redness): 4 people, 15.38%
  7. Itching: 4 people, 15.38%
  8. Nausea (feeling of having an urge to vomit): 4 people, 15.38%
  9. Nausea And Vomiting: 4 people, 15.38%
  10. Neck Pain: 4 people, 15.38%

* Approximation only. Some reports may have incomplete information.

Do you take Rizatriptan benzoate and Provigil?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously



Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Rizatriptan benzoate and Provigil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Rizatriptan benzoate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Provigil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Rizatriptan benzoate and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Provigil and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on rizatriptan benzoate and modafinil (the active ingredients of Rizatriptan benzoate and Provigil, respectively), and Rizatriptan benzoate and Provigil (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



Recent studies on eHealthMe: