Robaxisal and Profen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Robaxisal (aspirin; methocarbamol) and Profen (ibuprofen). Common drug interactions include dyspnoea among females and suicide attempt among males.

The phase IV clinical study analyzes what interactions people have when they take Robaxisal and Profen. It is created by eHealthMe based on reports of 61 people who take the same drugs from the FDA, and is updated regularly.

What is Robaxisal?

Robaxisal has active ingredients of aspirin; methocarbamol. It is often used in back pain. eHealthMe is studying from 223 Robaxisal users. Check the latest studies of Robaxisal.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,311 Profen users. Check the latest studies of Profen.

On Jul, 27, 2026

61 people who take Robaxisal and Profen together, and have interactions are studied.

What are the common drug interactions of Robaxisal and Profen, by gender? *:

female:

Dyspnoea (difficult or laboured respiration)
Asthenia (weakness)
Anaphylactoid reaction (type of anaphylaxis that does not involve an allergic reaction but is due to direct mast cell degranulation)
Anxiety
Arthralgia (joint pain)
Asthma
Blood pressure increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Constipation
Dizziness

male:

Suicide attempt
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Proteinuria (presence of protein in the urine)
Cytomegalovirus enteritis (virus infection of intestine)
Diarrhoea
Electrolyte imbalance
Mycobacterium avium complex infection
Suicidal ideation
Abdominal pain
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)

What are the common drug interactions of Robaxisal and Profen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Suicide attempt
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Renal failure (kidney dysfunction)
Poisoning deliberate
Lactic acidosis (low ph in body tissues)
Dizziness
Nausea (feeling of having an urge to vomit)
Malaise (a feeling of general discomfort or uneasiness)
Tachypnoea (a condition of rapid breathing over 20 per minute)
Oliguria (not enough urine)

20-29:

n/a

30-39:

Hepatic failure (liver failure)

40-49:

Anaphylactoid reaction (type of anaphylaxis that does not involve an allergic reaction but is due to direct mast cell degranulation)
Dyspnoea (difficult or laboured respiration)
Hypovolaemia (a decreased volume of circulating blood in the body)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Urticaria (rash of round, red welts on the skin that itch intensely)

50-59:

Anxiety
Arthralgia (joint pain)
Asthma
Blood pressure increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Constipation
Dizziness
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

60+:

Asthenia (weakness)
Abdominal pain
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Duodenal ulcer
Duodenal ulcer haemorrhage (bleeding duodenal ulcer)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haemoglobin decreased
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Melaena (the passage of black, tarry stools)
Therapeutic response decreased (less preventive response)

What are the existing conditions these people have? *

Suicide Attempt: 9 people, 14.75%
Asthma: 6 people, 9.84%
Stress And Anxiety: 4 people, 6.56%

* Approximation only. Some reports may have incomplete information.

Do you take Robaxisal and Profen?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously