Robitussin and Risperidone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Robitussin (guaifenesin) and Risperidone (risperidone). Common drug interactions include gait disturbance among females and dysuria among males.

The phase IV clinical study analyzes what interactions people have when they take Robitussin and Risperidone. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Robitussin?

Robitussin has active ingredients of guaifenesin. eHealthMe is studying from 3,532 Robitussin users. Check the latest studies of Robitussin.

What is Risperidone?

Risperidone has active ingredients of risperidone. It is often used in bipolar disorder. eHealthMe is studying from 72,175 Risperidone users. Check the latest studies of Risperidone.



On Jul, 11, 2026

13 people who take Robitussin and Risperidone together, and have interactions are studied.

Robitussin and Risperidone drug interactions.

What are the common drug interactions of Robitussin and Risperidone, by gender? *:

female:

  1. Gait disturbance
  2. Anger
  3. Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
  4. Delusion (a false belief or opinion)
  5. Dementia (madness)
  6. Disorientation (disability in which the senses of time, direction, and recognition of people and places)
  7. Hallucination (an experience involving the perception of something not present)
  8. Hip fracture
  9. Lethargy (tiredness)
  10. Aggression

male:

  1. Dysuria (painful or difficult urination)
  2. Hallucination (an experience involving the perception of something not present)
  3. Headache (pain in head)
  4. Psychotic disorder
  5. Suicide attempt
  6. Abnormal behaviour
  7. Agitation (state of anxiety or nervous excitement)
  8. Polysubstance dependence
  9. Substance abuse
  10. Substance-induced psychotic disorder

What are the common drug interactions of Robitussin and Risperidone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Dysuria (painful or difficult urination)
  2. Hallucination (an experience involving the perception of something not present)
  3. Abnormal behaviour
  4. Agitation (state of anxiety or nervous excitement)
  5. Polysubstance dependence
  6. Substance abuse
  7. Substance-induced psychotic disorder
  8. Tremor (trembling or shaking movements in one or more parts of your body)
  9. Drug abuse
  10. Drug dependence

20-29:

n/a

30-39:

n/a

40-49:

  1. Gait disturbance
  2. Anger
  3. Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
  4. Delusion (a false belief or opinion)
  5. Dementia (madness)
  6. Disorientation (disability in which the senses of time, direction, and recognition of people and places)
  7. Hallucination (an experience involving the perception of something not present)
  8. Hip fracture
  9. Lethargy (tiredness)
  10. Aggression

50-59:

  1. Ill-defined disorder

60+:

  1. Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
  2. Diarrhoea
  3. Syncope (loss of consciousness with an inability to maintain postural tone)
  4. Vomiting
  5. Dizziness
  6. Eye swelling
  7. Gastric disorder (disease of stomach)
  8. Hospitalisation
  9. Onychalgia (nail biting)
  10. Pneumonia

What are the existing conditions these people have? *

  1. Cough: 3 people, 23.08%
  2. Stress And Anxiety: 3 people, 23.08%
  3. Upper Respiratory Tract Infection: 2 people, 15.38%
  4. Constipation: 2 people, 15.38%
  5. Abnormal Behavior: 2 people, 15.38%
  6. Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur): 2 people, 15.38%
  7. Pain: 1 person, 7.69%
  8. Oropharyngeal Pain: 1 person, 7.69%
  9. Chronic Inflammatory Demyelinating Polyradiculoneuropathy (long lasting infection of nerves outside brain and spinal cord): 1 person, 7.69%
  10. Circadian Rhythm Sleep Disorder (family of sleep disorders affecting, among other things, the timing of sleep): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Robitussin and Risperidone:

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Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Robitussin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Risperidone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Robitussin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Risperidone and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on guaifenesin and risperidone (the active ingredients of Robitussin and Risperidone, respectively), and Robitussin and Risperidone (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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