Rocephin and Loperamide hydrochloride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rocephin (ceftriaxone sodium) and Loperamide hydrochloride (loperamide hydrochloride). Common drug interactions include tenderness among females and encephalopathy among males.

The phase IV clinical study analyzes what interactions people have when they take Rocephin and Loperamide hydrochloride. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Rocephin?

Rocephin has active ingredients of ceftriaxone sodium. It is often used in infection. eHealthMe is studying from 15,665 Rocephin users. Check the latest studies of Rocephin.

What is Loperamide hydrochloride?

Loperamide hydrochloride has active ingredients of loperamide hydrochloride. It is often used in diarrhea. eHealthMe is studying from 10,814 Loperamide hydrochloride users. Check the latest studies of Loperamide hydrochloride.



On Jul, 17, 2026

19 people who take Rocephin and Loperamide hydrochloride together, and have interactions are studied.

Rocephin and Loperamide hydrochloride drug interactions.

What are the common drug interactions of Rocephin and Loperamide Hydrochloride, by gender? *:

female:

  1. Tenderness (pain or discomfort when an affected area is touched)
  2. Upper respiratory tract inflammation
  3. Viral infection
  4. Vomiting
  5. Weight decreased
  6. Weight increased
  7. White blood cell count increased
  8. Arthralgia (joint pain)
  9. Chronic kidney disease
  10. Colon cancer metastatic (cancer of colon spreads to other part of body)

male:

  1. Encephalopathy (functioning of the brain is affected by some agent or condition)
  2. Angina pectoris (chest pain due to ischemia of the heart muscle)
  3. Pyrexia (fever)
  4. Respiratory failure (inadequate gas exchange by the respiratory system)
  5. Syncope (loss of consciousness with an inability to maintain postural tone)
  6. Tachycardia (a heart rate that exceeds the range of 100 beats/min)
  7. Thermal burn (burn by heat)
  8. Asthenia (weakness)
  9. Cardiac arrest
  10. Colitis ulcerative (inflammation of colon with ulcer)

What are the common drug interactions of Rocephin and Loperamide Hydrochloride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Asthenia (weakness)
  2. Colitis ulcerative (inflammation of colon with ulcer)
  3. Delirium (wild excitement)
  4. General physical health deterioration (weak health status)
  5. Pain
  6. Post procedural complication
  7. Pyrexia (fever)
  8. Syncope (loss of consciousness with an inability to maintain postural tone)
  9. Tachycardia (a heart rate that exceeds the range of 100 beats/min)

30-39:

  1. Gastric ulcer (stomach ulcer)
  2. Gastroenteritis (inflammation of stomach and intestine)
  3. Hypersensitivity
  4. Immunosuppression
  5. Nasopharyngitis (inflammation of the nasopharynx)
  6. Osteoporosis (bones weak and more likely to break)
  7. Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
  8. Pyrexia (fever)
  9. Seasonal allergy (allergic condition due to certain season)
  10. Skin erosion (a discontinuity of the skin)

40-49:

n/a

50-59:

  1. Encephalopathy (functioning of the brain is affected by some agent or condition)
  2. Multi-organ failure (multisystem organ failure)
  3. Pathogen resistance
  4. Abdominal rigidity
  5. Ascites (accumulation of fluid in the abdominal cavity)
  6. Cardiac arrest
  7. Chronic kidney disease
  8. Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
  9. Gastrointestinal mucosal necrosis (damage of mucous membrane in gastrointestinal tract)
  10. Gastrointestinal necrosis (destruction of gastrointestinal organ)

60+:

  1. Arthralgia (joint pain)
  2. Colon cancer metastatic (cancer of colon spreads to other part of body)
  3. Hepatic enzyme increased
  4. Hyperglycaemia (high blood sugar)
  5. Hypokalaemia (low potassium)
  6. Intervertebral disc degeneration (spinal disc degeneration)
  7. Microcytic anaemia (a generic term for any type of anaemia characterized by small red blood cells)
  8. Muscle strain (an injury to a muscle in which the muscle fibres tear)
  9. Oedema (fluid collection in tissue)
  10. Pain

What are the existing conditions these people have? *

  1. Pain: 5 people, 26.32%
  2. Hypocalcaemia (levels of calcium in blood serum are abnormally low): 4 people, 21.05%
  3. Back Pain: 4 people, 21.05%
  4. Bone Disorder: 4 people, 21.05%
  5. Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 4 people, 21.05%
  6. Diabetes: 4 people, 21.05%
  7. Essential Hypertension (primary hypertension): 4 people, 21.05%
  8. Stress And Anxiety: 3 people, 15.79%
  9. Oedema (fluid collection in tissue): 3 people, 15.79%
  10. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 15.79%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Rocephin and Loperamide hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Rocephin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Loperamide hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Rocephin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Loperamide hydrochloride and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on ceftriaxone sodium and loperamide hydrochloride (the active ingredients of Rocephin and Loperamide hydrochloride, respectively), and Rocephin and Loperamide hydrochloride (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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