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Rocephin and Mepergan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rocephin (ceftriaxone sodium) and Mepergan (meperidine hydrochloride; promethazine hydrochloride). Common drug interactions include aplastic anaemia among females.

The phase IV clinical study analyzes what interactions people have when they take Rocephin and Mepergan. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Rocephin?

Rocephin has active ingredients of ceftriaxone sodium. It is often used in infection. eHealthMe is studying from 15,665 Rocephin users. Check the latest studies of Rocephin.

What is Mepergan?

Mepergan has active ingredients of meperidine hydrochloride; promethazine hydrochloride. It is often used in pain. eHealthMe is studying from 211 Mepergan users. Check the latest studies of Mepergan.

On Jul, 13, 2026

13 people who take Rocephin and Mepergan together, and have interactions are studied.

Rocephin and Mepergan drug interactions.

What are the common drug interactions of Rocephin and Mepergan, by gender? *:

female:

  1. Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
  2. Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
  3. Polyhydramnios (excess of amniotic fluid in the amniotic sac)
  4. Bone marrow depression (decreased ability or inability of the bone marrow to produce blood cells)
  5. Petechiae (a small red or purple spot caused by bleeding into the skin)
  6. Abdominal pain
  7. Back pain
  8. Bacterial infection
  9. Diarrhoea
  10. Epistaxis (bleed from the nose)

male:

n/a

What are the common drug interactions of Rocephin and Mepergan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

  1. Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
  2. Gastrointestinal disorder (functional problems of gastrointestinal tract)
  3. Vaginal disorder
  4. Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
  5. Localised exfoliation (a peeling off or loss of epidermis at the site of exposure)
  6. Skin disorder (skin disease)
  7. Anaemia neonatal
  8. Bone marrow depression (decreased ability or inability of the bone marrow to produce blood cells)
  9. Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
  10. Pregnancy

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

n/a

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Rocephin and Mepergan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Rocephin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Mepergan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Rocephin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Mepergan and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on ceftriaxone sodium and meperidine hydrochloride; promethazine hydrochloride (the active ingredients of Rocephin and Mepergan, respectively), and Rocephin and Mepergan (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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