Rocephin and Rifadin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rocephin (ceftriaxone sodium) and Rifadin (rifampin). Common drug interactions include erysipelas among females and drug rash with eosinophilia and systemic symptoms among males.

The phase IV clinical study analyzes what interactions people have when they take Rocephin and Rifadin. It is created by eHealthMe based on reports of 62 people who take the same drugs from the FDA, and is updated regularly.

What is Rocephin?

Rocephin has active ingredients of ceftriaxone sodium. It is often used in infection. eHealthMe is studying from 15,665 Rocephin users. Check the latest studies of Rocephin.

What is Rifadin?

Rifadin has active ingredients of rifampin. eHealthMe is studying from 2,104 Rifadin users. Check the latest studies of Rifadin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

62 people who take Rocephin and Rifadin together, and have interactions are studied.

What are the common drug interactions of Rocephin and Rifadin, by gender? *:

female:

Erysipelas (bacterial skin infection)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Hypoxia (low oxygen in tissues)
Pulmonary embolism (blockage of the main artery of the lung)
Renal failure acute (rapid kidney dysfunction)
Renal insufficiency (insufficient excretion of wastes by the kidneys)
Rigors (an episode of shaking or exaggerated shivering)
Staphylococcal sepsis (blood infection by an infection with staphylococcus bacteria)
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)

male:

Drug rash with eosinophilia and systemic symptoms (adverse drug reactions with rash)
Pyrexia (fever)
Coagulation factor v level decreased
Dermatitis bullous (inflammation of the skin characterized by the presence of bullae which are filled with fluid)
Hepatitis (inflammation of the liver)
Hepatocellular damage (liver damage)
Hypertension (high blood pressure)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Photosensitivity reaction
Altered state of consciousness (altered state of mind)

What are the common drug interactions of Rocephin and Rifadin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Dermatitis bullous (inflammation of the skin characterized by the presence of bullae which are filled with fluid)
Photosensitivity reaction
Pseudoporphyria (skin changes consistent with one of the porphyrias, but laboratory tests do not detect significant abnormalities)

10-19:

Abdominal pain
Blood amylase increased
Pancreatitis (inflammation of pancreas)

20-29:

n/a

30-39:

Hypertension (high blood pressure)
Proteinuria (presence of protein in the urine)
Renal failure acute (rapid kidney dysfunction)
Histiocytosis haematophagic
Immune reconstitution syndrome (immune recovery syndrome)
Pruritus (severe itching of the skin)
Toxic skin eruption (skin breakdown due to toxic substance)
Blood creatinine increased
Blood triglycerides increased
General physical health deterioration (weak health status)

40-49:

Renal insufficiency (insufficient excretion of wastes by the kidneys)
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
Tendon rupture (tear of tendon)
Meningitis pneumococcal (a bacterial infection of the membranes covering the brain and spinal cord (meninges))
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Antinuclear antibody positive
Coagulation factor v level decreased
Coagulation factor vii level decreased
Coagulation factor x level decreased
Coagulopathy (blood's ability to clot is impaired)

50-59:

Blood pressure decreased
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Cross sensitivity reaction
Escherichia sepsis (bacterial infection by escherichia coli)
Lichenoid keratosis (a skin disorder described by rapid growing, reddish to brown, benign (noncancerous) lesion on the skin)
Lip oedema (swelling of lip)
Oedema peripheral (superficial swelling)
Proteinuria (presence of protein in the urine)
Pruritus (severe itching of the skin)
Pruritus generalised (generalized itching)

60+:

Drug rash with eosinophilia and systemic symptoms (adverse drug reactions with rash)
Pyrexia (fever)
Eosinophilia (eosinophil count in the peripheral blood exceeds)
Hepatitis (inflammation of the liver)
Hepatocellular damage (liver damage)
Liver disorder (liver diseases)
Pancreatic disorder
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Blood amylase increased
Blood fibrinogen decreased

What are the existing conditions these people have? *

Endocarditis (inflammation in heart muscle): 9 people, 14.52%
Tuberculosis (a bacterial infection by mycobacterium tuberculosis): 6 people, 9.68%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 8.06%
Meningitis Haemophilus (a bacterial infection of the membranes covering the brain and spinal cord (meninges)): 5 people, 8.06%
Urinary Tract Infection: 4 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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