Roflumilast and Isosorbide mononitrate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Roflumilast (roflumilast) and Isosorbide mononitrate (isosorbide mononitrate). Common drug interactions include infusion site extravasation among females.

The phase IV clinical study analyzes what interactions people have when they take Roflumilast and Isosorbide mononitrate. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Roflumilast?

Roflumilast has active ingredients of roflumilast. eHealthMe is studying from 2,247 Roflumilast users. Check the latest studies of Roflumilast.

What is Isosorbide mononitrate?

Isosorbide mononitrate has active ingredients of isosorbide mononitrate. It is often used in angina. eHealthMe is studying from 26,858 Isosorbide mononitrate users. Check the latest studies of Isosorbide mononitrate.

On Jul, 17, 2026

13 people who take Roflumilast and Isosorbide mononitrate together, and have interactions are studied.

Roflumilast and Isosorbide mononitrate drug interactions.

What are the common drug interactions of Roflumilast and Isosorbide Mononitrate, by gender? *:

female:

Infusion site extravasation (flow of (blood or lymph) from infusion site)
Metabolic disorder (an abnormal function and pattern of body fat. insulin resistance refers to the diminished ability of cells to respond to the action of insulin in promoting the transport of the sugar glucose, from blood into muscles and other tissues)
Malaise (a feeling of general discomfort or uneasiness)
Pharyngeal oedema (abnormal accumulation of fluid in the cavities and intercellular spaces of the pharyngeal)
Pneumonia
Rectal haemorrhage (bleeding from anus)
Visual impairment
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Catheter site haemorrhage (bleeding at catheter site)
Cellulitis (infection under the skin)

male:

n/a

What are the common drug interactions of Roflumilast and Isosorbide Mononitrate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Blood pressure decreased
Cardiac failure congestive
Rectal haemorrhage (bleeding from anus)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Lipase increased
Loss of consciousness
Nausea (feeling of having an urge to vomit)
Pain
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Clavicle fracture

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 3 people, 23.08%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 2 people, 15.38%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 2 people, 15.38%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 15.38%
Pulmonary Embolism (blockage of the main artery of the lung): 1 person, 7.69%
Pain: 1 person, 7.69%
Embolism Venous (embolus may pass into the arterial system): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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