Roxicodone and Ceftriaxone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Roxicodone (oxycodone hydrochloride) and Ceftriaxone (ceftriaxone sodium). Common drug interactions include hyperosmolar state among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Roxicodone and Ceftriaxone. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Roxicodone?

Roxicodone has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 20,099 Roxicodone users. Check the latest studies of Roxicodone.

What is Ceftriaxone?

Ceftriaxone has active ingredients of ceftriaxone sodium. It is often used in typhoid fever. eHealthMe is studying from 40,991 Ceftriaxone users. Check the latest studies of Ceftriaxone.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

33 people who take Roxicodone and Ceftriaxone together, and have interactions are studied.

Roxicodone and Ceftriaxone drug interactions.

What are the common drug interactions of Roxicodone and Ceftriaxone, by gender? *:

female:

Hyperosmolar state (life-threatening emergency manifested by marked elevation of blood glucose)
Hypokalaemia (low potassium)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)
Hypotension (abnormally low blood pressure)
Immunosuppression
Juvenile idiopathic arthritis (a subset of arthritis seen in childhood)
Limb asymmetry (consistent task discrepancy between the two lower limbs)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Mineral deficiency (lack of mineral)

male:

Pneumonia
Sepsis (a severe blood infection that can lead to organ failure and death)
Abdominal pain
Accidental poisoning
Acute respiratory distress syndrome
Alanine aminotransferase increased
Anxiety
Arthralgia (joint pain)
Aspartate aminotransferase increased
Back pain

What are the common drug interactions of Roxicodone and Ceftriaxone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Drug ineffective
Sepsis (a severe blood infection that can lead to organ failure and death)
Urinary tract infection bacterial

10-19:

Hypotension (abnormally low blood pressure)
Immunosuppression
Juvenile idiopathic arthritis (a subset of arthritis seen in childhood)
Limb asymmetry (consistent task discrepancy between the two lower limbs)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Mineral deficiency (lack of mineral)
Mobility decreased (ability to move is reduced)
Myocardial strain
Nephrogenic anaemia (anaemia due to kidney disease)
Obesity (having too much body fat)

20-29:

Intracranial venous sinus thrombosis (presence of thrombosis (a blood clot) in the dural venous sinuses, which drain blood from the brain)
Jugular vein thrombosis (clot in jugular vein)

30-39:

Accidental poisoning
Acute respiratory distress syndrome
Arthralgia (joint pain)
Chest pain
Cough
Death
Fibrin d dimer increased
Hyperhidrosis (abnormally increased sweating)
Myalgia (muscle pain)
Pneumonia

40-49:

Colorectal cancer metastatic (cancer of colon and rectal spreads to other parts)
Embolism (obstruction of an artery, typically by a clot of blood or an air bubble)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Oedema peripheral (superficial swelling)
Retroperitoneal lymphadenopathy (disease of lymph node between peritoneum and the posterior abdominal wall)
Venous occlusion (the blocking of venous return)
Venous thrombosis (blood clot (thrombus) that forms within a vein)
Headache (pain in head)
Sepsis (a severe blood infection that can lead to organ failure and death)
Burkholderia cepacia complex infection (complex infection by group of bacteria burkholderia cepacia -resistant to common antibiotics)

50-59:

Burkholderia test positive
Respiratory disorder (respiratory disease)
Sputum culture positive
Syncope (loss of consciousness with an inability to maintain postural tone)

60+:

Pneumonia
Sepsis (a severe blood infection that can lead to organ failure and death)
Renal tubular necrosis (death of kidney tubules)
Abdominal pain
Alanine aminotransferase increased
Anxiety
Aspartate aminotransferase increased
Back pain
Blood alkaline phosphatase increased
Constipation

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 10 people, 30.30%
Urinary Tract Infection: 5 people, 15.15%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 4 people, 12.12%
Pneumonia: 4 people, 12.12%
Fever: 4 people, 12.12%
High Blood Cholesterol: 3 people, 9.09%
High Blood Pressure: 3 people, 9.09%
Spinal Compression Fracture (fracture due to spinal compression on bone): 2 people, 6.06%
Muscle Spasms (muscle contraction): 2 people, 6.06%
Constipation: 2 people, 6.06%

* Approximation only. Some reports may have incomplete information.

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