Rozerem and Suboxone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rozerem (ramelteon) and Suboxone (buprenorphine hydrochloride; naloxone hydrochloride). Common drug interactions include pancreatitis among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Rozerem and Suboxone. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Rozerem?

Rozerem has active ingredients of ramelteon. It is often used in insomnia. eHealthMe is studying from 7,539 Rozerem users. Check the latest studies of Rozerem.

What is Suboxone?

Suboxone has active ingredients of buprenorphine hydrochloride; naloxone hydrochloride. It is often used in opiate withdrawal. eHealthMe is studying from 31,249 Suboxone users. Check the latest studies of Suboxone.

On Jul, 14, 2026

12 people who take Rozerem and Suboxone together, and have interactions are studied.

What are the common drug interactions of Rozerem and Suboxone, by gender? *:

female:

Pancreatitis (inflammation of pancreas)
Pancreatitis acute (sudden inflammation of pancreas)
Pneumonia
Pulmonary embolism (blockage of the main artery of the lung)
Adverse drug reaction
Endocarditis (inflammation in heart muscle)
Migraine (headache)
Nausea (feeling of having an urge to vomit)
Tongue blistering
Foot fracture

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Wrist fracture
Depression
Emotional distress
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Osteopenia (a condition where bone mineral density is lower than normal)
Pain
Rib fracture
Fall

What are the common drug interactions of Rozerem and Suboxone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Pancreatitis (inflammation of pancreas)
Pancreatitis acute (sudden inflammation of pancreas)
Adverse drug reaction
Endocarditis (inflammation in heart muscle)
Migraine (headache)
Nausea (feeling of having an urge to vomit)
Pneumonia
Pulmonary embolism (blockage of the main artery of the lung)
Tongue blistering

30-39:

Death
Abasia (inability to walk)
Bone density decreased
Chest pain
Injection site bruising
Injection site erythema (redness at injection site)
Memory impairment
Nasopharyngitis (inflammation of the nasopharynx)
Oedema peripheral (superficial swelling)
Pain

40-49:

Fall

50-59:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Depression
Emotional distress
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Osteopenia (a condition where bone mineral density is lower than normal)
Pain
Rib fracture
Upper limb fracture
Wrist fracture

60+:

n/a

What are the existing conditions these people have? *

Depression: 7 people, 58.33%
Bipolar Disorder (mood disorder): 5 people, 41.67%
Stress And Anxiety: 4 people, 33.33%
Nausea (feeling of having an urge to vomit): 3 people, 25.00%
Chest Pain: 3 people, 25.00%
Pain: 2 people, 16.67%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 16.67%
Hiv Infection: 2 people, 16.67%
Sleep Disorder: 1 person, 8.33%
Osteoporosis (bones weak and more likely to break): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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