Rybelsus and Benadryl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rybelsus (semaglutide) and Benadryl (diphenhydramine hydrochloride). Common drug interactions include urinary tract infection among females and chills among males.

The phase IV clinical study analyzes what interactions people have when they take Rybelsus and Benadryl. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Rybelsus?

Rybelsus has active ingredients of semaglutide. eHealthMe is studying from 4,159 Rybelsus users. Check the latest studies of Rybelsus.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,954 Benadryl users. Check the latest studies of Benadryl.

On Jul, 12, 2026

16 people who take Rybelsus and Benadryl together, and have interactions are studied.

Rybelsus and Benadryl drug interactions.

What are the common drug interactions of Rybelsus and Benadryl, by gender? *:

female:

Urinary tract infection
Pain
Alopecia (absence of hair from areas of the body)
Anaphylactic reaction (serious allergic reaction)
Dizziness
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Kidney infection
Nausea (feeling of having an urge to vomit)
Oropharyngeal pain
Procedural pain

male:

Chills (felling of cold)
Dry mouth
Dry throat
Feeling jittery
Heart rate increased
Miosis (constriction of the pupil of the eye, resulting from a normal response to an increase in light)
Renal pain (kidney pain)
Throat tightness
Urinary retention (the inability to completely or partially empty the bladder)
Vision blurred

What are the common drug interactions of Rybelsus and Benadryl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Epistaxis (bleed from the nose)
Oropharyngeal pain

30-39:

n/a

40-49:

Anaphylactic reaction (serious allergic reaction)
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Kidney infection
Procedural pain
Urinary tract infection
Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Asthma
Dizziness
Headache (pain in head)
Pneumonia

50-59:

n/a

60+:

Chills (felling of cold)
Dry mouth
Glycosylated haemoglobin increased
Neck pain
Swelling
Swelling face
Dry throat
Feeling jittery
Heart rate increased
Miosis (constriction of the pupil of the eye, resulting from a normal response to an increase in light)

What are the existing conditions these people have? *

Essential Thrombocythaemia (chronic blood cancer): 6 people, 37.50%
Hidradenitis (chronic disease of a type of sweat gland): 4 people, 25.00%
Adverse Drug Reaction: 2 people, 12.50%
Pericarditis Lupus (inflammation of the pericardium with red ulcerations on the face): 2 people, 12.50%
Immunodeficiency Common Variable: 2 people, 12.50%
Hyperglycemia (high blood sugar): 1 person, 6.25%
Cushing's Syndrome (obesity, a rounded face, increased fat): 1 person, 6.25%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 1 person, 6.25%
Gastritis (inflammation of stomach): 1 person, 6.25%
Glaucoma (increased fluid pressure in the eye with vision loss): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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