Rybelsus and Glucophage drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rybelsus (semaglutide) and Glucophage (metformin hydrochloride). Common drug interactions include blood glucose increased among females and abdominal distension among males.

The phase IV clinical study analyzes what interactions people have when they take Rybelsus and Glucophage. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Rybelsus?

Rybelsus has active ingredients of semaglutide. eHealthMe is studying from 4,159 Rybelsus users. Check the latest studies of Rybelsus.

What is Glucophage?

Glucophage has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 60,851 Glucophage users. Check the latest studies of Glucophage.

On Jul, 27, 2026

14 people who take Rybelsus and Glucophage together, and have interactions are studied.

Rybelsus and Glucophage drug interactions.

What are the common drug interactions of Rybelsus and Glucophage, by gender? *:

female:

Blood glucose increased
Dizziness
Aortic arteriosclerosis (hardening of the aortic arteries)
Arterial disorder
Arteriosclerosis (thickening and hardening of arteries)
Cerebral microangiopathy (small-vessel disease of brain)
Defaecation urgency (a sudden compelling urge to defecate)
Diarrhoea
Gait disturbance
Hyperplasia (enlargement of an organ or tissue)

male:

Abdominal distension
Abdominal pain upper
Diarrhoea
Fatigue (feeling of tiredness)
Lactic acidosis (low ph in body tissues)
Muscle atrophy (a decrease in the mass of the muscle)
Pemphigoid (tense blisters on the skin)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Hypogonadism male (male testes produce little or no sex hormone)
Weight decreased

What are the common drug interactions of Rybelsus and Glucophage, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Syncope (loss of consciousness with an inability to maintain postural tone)

60+:

Diarrhoea
Abdominal distension
Arterial disorder
Arteriosclerosis (thickening and hardening of arteries)
Cerebral microangiopathy (small-vessel disease of brain)
Defaecation urgency (a sudden compelling urge to defecate)
Dehydration (dryness resulting from the removal of water)
Fatigue (feeling of tiredness)
Gait disturbance
Hyperplasia (enlargement of an organ or tissue)

What are the existing conditions these people have? *

Type 2 Diabetes: 7 people, 50.00%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 14.29%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 14.29%
High Blood Pressure: 2 people, 14.29%
Wheezing (a high-pitched whistling sound made while you breath): 1 person, 7.14%
Psoriasis (immune-mediated disease that affects the skin): 1 person, 7.14%
Pain: 1 person, 7.14%
Neck Pain: 1 person, 7.14%
Nausea (feeling of having an urge to vomit): 1 person, 7.14%
Muscle Spasms (muscle contraction): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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