Rybelsus and Lasix drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rybelsus (semaglutide) and Lasix (furosemide). Common drug interactions include malaise among females and chest pain among males.

The phase IV clinical study analyzes what interactions people have when they take Rybelsus and Lasix. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Rybelsus?

Rybelsus has active ingredients of semaglutide. eHealthMe is studying from 4,159 Rybelsus users. Check the latest studies of Rybelsus.

What is Lasix?

Lasix has active ingredients of furosemide. It is often used in swelling. eHealthMe is studying from 210,439 Lasix users. Check the latest studies of Lasix.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

22 people who take Rybelsus and Lasix together, and have interactions are studied.

What are the common drug interactions of Rybelsus and Lasix, by gender? *:

female:

Malaise (a feeling of general discomfort or uneasiness)
Fall
Bone pain
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Fractured coccyx (fracture tail bone)
Headache (pain in head)
Infection
Pain
Pain in jaw
Pancreatitis (inflammation of pancreas)

male:

Chest pain
Fatigue (feeling of tiredness)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Dizziness
Dyspnoea (difficult or laboured respiration)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Lethargy (tiredness)
Lung neoplasm malignant (cancer tumour of lung)
Neoplasm (tumour)
Pemphigoid (tense blisters on the skin)

What are the common drug interactions of Rybelsus and Lasix, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Blood glucose increased
Chest pain
Glomerular filtration rate decreased
Malaise (a feeling of general discomfort or uneasiness)
Pulseless electrical activity
Disease recurrence
Drug ineffective

40-49:

Renal impairment (severely reduced kidney function)
Thirst

50-59:

Malaise (a feeling of general discomfort or uneasiness)
Bone pain
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Fall
Fractured coccyx (fracture tail bone)
Headache (pain in head)
Infection
Pain
Pain in jaw
Pancreatitis (inflammation of pancreas)

60+:

Fatigue (feeling of tiredness)
Asthenia (weakness)
Dyspnoea (difficult or laboured respiration)
Epistaxis (bleed from the nose)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Lethargy (tiredness)
Lung neoplasm malignant (cancer tumour of lung)
Memory impairment
Neoplasm (tumour)
Neutropenia (an abnormally low number of neutrophils)

What are the existing conditions these people have? *

Type 2 Diabetes: 6 people, 27.27%
High Blood Pressure: 4 people, 18.18%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 13.64%
Urination - Excessive Volume: 2 people, 9.09%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 9.09%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 2 people, 9.09%
Oedema (fluid collection in tissue): 2 people, 9.09%
Multiple Myeloma (cancer of the plasma cells): 2 people, 9.09%
Hyperparathyroidism Secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary): 2 people, 9.09%
High Blood Cholesterol: 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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