Rybelsus and Linagliptin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rybelsus (semaglutide) and Linagliptin (linagliptin). Common drug interactions include hypoaesthesia among females and cholangitis among males.

The phase IV clinical study analyzes what interactions people have when they take Rybelsus and Linagliptin. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Rybelsus?

Rybelsus has active ingredients of semaglutide. eHealthMe is studying from 4,159 Rybelsus users. Check the latest studies of Rybelsus.

What is Linagliptin?

Linagliptin has active ingredients of linagliptin. eHealthMe is studying from 8,112 Linagliptin users. Check the latest studies of Linagliptin.

On Jul, 07, 2026

13 people who take Rybelsus and Linagliptin together, and have interactions are studied.

Rybelsus and Linagliptin drug interactions.

What are the common drug interactions of Rybelsus and Linagliptin, by gender? *:

female:

Hypoaesthesia (reduced sense of touch or sensation)
Vomiting
Blood glucose increased
Glycosylated haemoglobin increased
Diarrhoea
Eye degenerative disorder
Eye oedema (swelling or thickening of the macula, the area of the retina responsible for central vision)
Ageusia (loss of taste functions of the tongue)
Defaecation urgency (a sudden compelling urge to defecate)

male:

Cholangitis (infection of the bile duct)
Eructation (release of gas from the digestive tract)
Gastrointestinal disorder (functional problems of gastrointestinal tract)

What are the common drug interactions of Rybelsus and Linagliptin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Blood glucose increased
Glycosylated haemoglobin increased
Hypoaesthesia (reduced sense of touch or sensation)
Vomiting
Diarrhoea
Eye degenerative disorder
Eye oedema (swelling or thickening of the macula, the area of the retina responsible for central vision)
Ageusia (loss of taste functions of the tongue)
Cholangitis (infection of the bile duct)
Defaecation urgency (a sudden compelling urge to defecate)

What are the existing conditions these people have? *

Type 2 Diabetes: 5 people, 38.46%
Diabetes: 5 people, 38.46%
High Blood Cholesterol: 2 people, 15.38%
Indigestion: 1 person, 7.69%
High Blood Pressure: 1 person, 7.69%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 7.69%
Eosinophilic Pneumonia (eosinophil accumulates in the lung): 1 person, 7.69%
Blood Pressure Abnormal: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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