Rybelsus and Synjardy drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rybelsus (semaglutide) and Synjardy (empagliflozin; metformin hydrochloride). Common drug interactions include nausea among females and vomiting among males.

The phase IV clinical study analyzes what interactions people have when they take Rybelsus and Synjardy. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Rybelsus?

Rybelsus has active ingredients of semaglutide. eHealthMe is studying from 4,159 Rybelsus users. Check the latest studies of Rybelsus.

What is Synjardy?

Synjardy has active ingredients of empagliflozin; metformin hydrochloride. eHealthMe is studying from 2,928 Synjardy users. Check the latest studies of Synjardy.

On Aug, 11, 2026

14 people who take Rybelsus and Synjardy together, and have interactions are studied.

Rybelsus and Synjardy drug interactions.

What are the common drug interactions of Rybelsus and Synjardy, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Vomiting
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Hypophagia (reduced food intake)
Poor venous access
Abdominal distension
Abdominal pain upper
Decreased appetite
Eructation (release of gas from the digestive tract)
Fatigue (feeling of tiredness)

male:

Vomiting
Nausea (feeling of having an urge to vomit)
Food aversion (we reject certain foods for a reason)
Neuropathy peripheral (surface nerve damage)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Diarrhoea
Ketoacidosis (high concentrations of ketone bodies in blood)
Hypophagia (reduced food intake)
Poor venous access
Constipation

What are the common drug interactions of Rybelsus and Synjardy, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Decreased appetite
Fatigue (feeling of tiredness)
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Vaginal haemorrhage (vaginal bleeding)
Vomiting

40-49:

n/a

50-59:

Constipation
Nausea (feeling of having an urge to vomit)
Vomiting
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)

60+:

Vomiting
Nausea (feeling of having an urge to vomit)
Food aversion (we reject certain foods for a reason)
Ketosis (a state of elevated levels of ketone bodies in the body)
Loss of consciousness
Hypophagia (reduced food intake)
Ketoacidosis (high concentrations of ketone bodies in blood)
Poor venous access
Diarrhoea
Syncope (loss of consciousness with an inability to maintain postural tone)

What are the existing conditions these people have? *

Diabetes: 7 people, 50.00%
Type 2 Diabetes: 3 people, 21.43%
Cushing's Syndrome (obesity, a rounded face, increased fat): 2 people, 14.29%
Depression: 1 person, 7.14%
Diarrhea: 1 person, 7.14%
Headache (pain in head): 1 person, 7.14%
High Blood Pressure: 1 person, 7.14%
Hypokalemia (low potassium): 1 person, 7.14%
Hypotension (abnormally low blood pressure): 1 person, 7.14%
Vitiligo (pigment is lost from areas of the skin): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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