Rythmol and Profen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rythmol (propafenone hydrochloride) and Profen (ibuprofen). Common drug interactions include pancreatitis acute among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Rythmol and Profen. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Rythmol?

Rythmol has active ingredients of propafenone hydrochloride. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 3,638 Rythmol users. Check the latest studies of Rythmol.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,311 Profen users. Check the latest studies of Profen.

On Aug, 13, 2026

16 people who take Rythmol and Profen together, and have interactions are studied.

What are the common drug interactions of Rythmol and Profen, by gender? *:

female:

Pancreatitis acute (sudden inflammation of pancreas)
Appendicitis perforated (perforated appendicitis is a condition in which an inflamed appendix bursts)
Abnormal dreams
Abnormal faeces (abnormal stool)
Anxiety
Cardiovascular disorder (heart diseases)
Chronic kidney disease
Constipation
Cough
Decreased appetite

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Constipation
Dry eye (lack of adequate tears)
Dry mouth
Dysgeusia (disorder of the sense of taste)
Dyspnoea exertional (breathlessness or shortness of breath)
Eye irritation
Fluid overload (too much fluid in the blood)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

What are the common drug interactions of Rythmol and Profen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Chronic kidney disease
Renal disorder (kidney disease)
Renal failure (kidney dysfunction)
Renal injury (kidney injury)

50-59:

Nervous system disorder (a general class of medical conditions affecting the nervous system)
Neuropathy peripheral (surface nerve damage)
Anxiety
Cardiac failure
Cardiovascular disorder (heart diseases)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Dyspepsia (indigestion)
Emotional distress
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Fatigue (feeling of tiredness)

60+:

Chronic kidney disease
Pancreatitis acute (sudden inflammation of pancreas)
Abnormal sensation in eye
Anaphylactic reaction (serious allergic reaction)
Arthralgia (joint pain)
Blood creatinine increased
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Cough
Decreased appetite

What are the existing conditions these people have? *

High Blood Pressure: 5 people, 31.25%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 25.00%
Asthma: 4 people, 25.00%
Nasal Congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels): 3 people, 18.75%
Stress And Anxiety: 3 people, 18.75%
High Blood Cholesterol: 3 people, 18.75%
Hypersensitivity: 3 people, 18.75%
Depression: 3 people, 18.75%
Infection: 3 people, 18.75%
Joint Pain: 3 people, 18.75%

* Approximation only. Some reports may have incomplete information.

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