Rythmol and Zestril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rythmol (propafenone hydrochloride) and Zestril (lisinopril). Common drug interactions include cerebrovascular disorder among females and weight increased among males.

The phase IV clinical study analyzes what interactions people have when they take Rythmol and Zestril. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Rythmol?

Rythmol has active ingredients of propafenone hydrochloride. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 3,638 Rythmol users. Check the latest studies of Rythmol.

What is Zestril?

Zestril has active ingredients of lisinopril. It is often used in high blood pressure. eHealthMe is studying from 22,273 Zestril users. Check the latest studies of Zestril.

On Jul, 17, 2026

48 people who take Rythmol and Zestril together, and have interactions are studied.

What are the common drug interactions of Rythmol and Zestril, by gender? *:

female:

Cerebrovascular disorder (disease of brain)
Cervical myelopathy (clinical syndrome characterized by clumsiness in hands; gait imbalance; caused by compression of the spinal cord)
Disability
Emotional distress
Fear
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hypotension (abnormally low blood pressure)
Injury
Intervertebral disc degeneration (spinal disc degeneration)
Keratitis (eye's cornea, the front part of the eye, becomes inflamed)

male:

Weight increased
Chest pain
Pain
Skin amp subcutaneous tissue abscess (infection of the skin and subcutaneous tissue)
Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart)
Abdominal distension
Abdominal pain
Anxiety
Ascites (accumulation of fluid in the abdominal cavity)
Atrioventricular block (heart block)

What are the common drug interactions of Rythmol and Zestril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

International normalised ratio increased
Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)

50-59:

Cardiogenic shock (inadequate circulation of blood)
Coagulopathy (blood's ability to clot is impaired)
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)
Hostility

60+:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Pain
Chest pain
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Constipation
Fatigue (feeling of tiredness)
Foot ulcer
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Hepatocellular damage (liver damage)
Hypokalaemia (low potassium)

What are the existing conditions these people have? *

Tumor: 3 people, 6.25%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 3 people, 6.25%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 3 people, 6.25%
Depression: 3 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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