Sabril and Synthroid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sabril (vigabatrin) and Synthroid (levothyroxine sodium). Common drug interactions include hypothermia among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Sabril and Synthroid. It is created by eHealthMe based on reports of 55 people who take the same drugs from the FDA, and is updated regularly.

What is Sabril?

Sabril has active ingredients of vigabatrin. eHealthMe is studying from 12,445 Sabril users. Check the latest studies of Sabril.

What is Synthroid?

Synthroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 249,205 Synthroid users. Check the latest studies of Synthroid.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

55 people who take Sabril and Synthroid together, and have interactions are studied.

What are the common drug interactions of Sabril and Synthroid, by gender? *:

female:

Hypothermia (body temperature drops below the required temperature for normal metabolism and body functions)
Hypotonia (low muscle tone)
Infantile spasms
Influenza
Intestinal ischaemia (decreased supply of oxygenated blood to the intestines)
Ischaemia (insufficient supply of blood to an organ, usually due to a blocked artery)
Lactic acidosis (low ph in body tissues)
Multi-organ failure (multisystem organ failure)
Mydriasis (a dilation of the pupil)
Post procedural complication

male:

Pyrexia (fever)
Pneumonia
Sepsis (a severe blood infection that can lead to organ failure and death)
Skin warm
Weight decreased
Staphylococcal abscess (pus formation due to staphylococcal bacteria)
Hypothermia (body temperature drops below the required temperature for normal metabolism and body functions)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Death
Staphylococcal infection (an infection with staphylococcus bacteria)

What are the common drug interactions of Sabril and Synthroid, by age (0-1 to 60+)? *:

0-1:

Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Diabetes mellitus inadequate control
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Hypotension (abnormally low blood pressure)
Hypotonia (low muscle tone)
Infantile spasms
Intestinal ischaemia (decreased supply of oxygenated blood to the intestines)
Ischaemia (insufficient supply of blood to an organ, usually due to a blocked artery)
Lactic acidosis (low ph in body tissues)

2-9:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Death
Urinary tract infection
Hypothermia (body temperature drops below the required temperature for normal metabolism and body functions)
Pneumonia
Post procedural complication
Respiratory distress (difficulty in breathing)
Respiratory failure (inadequate gas exchange by the respiratory system)
Upper respiratory tract infection
Acute respiratory distress syndrome

10-19:

Death
Abdominal distension
Influenza
Pneumonia
Respiratory failure (inadequate gas exchange by the respiratory system)
Urinary tract infection

20-29:

Cellulitis (infection under the skin)
Erythema (redness of the skin)
Infection
Localised infection (infection at the single location)
Neck mass (mass in neck)
Peripheral swelling
Pneumonia
Pyrexia (fever)
Respiratory tract infection
Sensitisation (the state of being sensitive)

30-39:

n/a

40-49:

Attention deficit/hyperactivity disorder
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Balance disorder
Confusional state
Delusion (a false belief or opinion)
Fall
Pleural fibrosis (formation of fibrous tissue in lung)
Renal failure acute (rapid kidney dysfunction)
Somnambulism (sleep walking)
Suicide attempt

50-59:

Death
Asthma
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Drug withdrawal convulsions
Pyrexia (fever)
Retinal toxicity (retina damage due to medication)
Retinopathy (acute damage to the retina of the eye)
Upper respiratory tract infection

60+:

n/a

What are the existing conditions these people have? *

Infantile Spasms: 17 people, 30.91%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 17 people, 30.91%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 10 people, 18.18%
Brain Neoplasm Benign (non-cancerous tumour of brain): 7 people, 12.73%
Astrocytoma, Low Grade (low grade tumour of the brain that originate in a particular kind of glial-cells): 7 people, 12.73%
Pain: 4 people, 7.27%
Partial Seizures (seizures which affect only a part of the brain at onset): 3 people, 5.45%
Fever: 3 people, 5.45%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 3 people, 5.45%
Constipation: 3 people, 5.45%

* Approximation only. Some reports may have incomplete information.

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