Salonpas and Metformin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Salonpas (menthol; methyl salicylate) and Metformin (metformin hydrochloride). Common drug interactions include drug ineffective among females and application site pain among males.

The phase IV clinical study analyzes what interactions people have when they take Salonpas and Metformin. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Salonpas?

Salonpas has active ingredients of menthol; methyl salicylate. eHealthMe is studying from 630 Salonpas users. Check the latest studies of Salonpas.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,354 Metformin users. Check the latest studies of Metformin.



On Jul, 27, 2026

26 people who take Salonpas and Metformin together, and have interactions are studied.

Salonpas and Metformin drug interactions.

What are the common drug interactions of Salonpas and Metformin, by gender? *:

female:

  1. Drug ineffective
  2. Chronic left ventricular failure (long lasting functional impairment of left ventricle of heart)
  3. Dry eye (lack of adequate tears)
  4. Renal disorder (kidney disease)
  5. Application site rash
  6. Weight decreased
  7. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  8. Pain
  9. Application site burn
  10. Application site erythema (redness of the skin at application site)

male:

  1. Application site pain
  2. Back pain
  3. Neck injury
  4. Neck pain
  5. Pain
  6. Pain in extremity
  7. Peripheral coldness
  8. Poor quality sleep
  9. Respiratory disorder (respiratory disease)
  10. Application site erythema (redness of the skin at application site)

What are the common drug interactions of Salonpas and Metformin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Application site burn
  2. Application site erythema (redness of the skin at application site)
  3. Application site pain
  4. Application site scar
  5. Cellulitis (infection under the skin)
  6. Chemical injury
  7. Diabetic ulcer
  8. Drug ineffective
  9. Dry gangrene (diminished blood supply due to vascular problems)
  10. Eschar (dead tissue that falls off (sheds) from healthy skin)

50-59:

  1. Hypersensitivity
  2. Malaise (a feeling of general discomfort or uneasiness)
  3. Nasopharyngitis (inflammation of the nasopharynx)
  4. Overdose
  5. Respiratory depression (respiration has a rate below 12 breaths)

60+:

  1. Pain
  2. Fatigue (feeling of tiredness)
  3. Infusion related reaction
  4. Nasopharyngitis (inflammation of the nasopharynx)
  5. Neck injury
  6. Neck pain
  7. Pain in extremity
  8. Peripheral coldness
  9. Poor quality sleep
  10. Respiratory disorder (respiratory disease)

What are the existing conditions these people have? *

  1. Pain: 7 people, 26.92%
  2. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 15.38%
  3. High Blood Pressure: 3 people, 11.54%
  4. Arthritis (form of joint disorder that involves inflammation of one or more joints): 3 people, 11.54%
  5. Immunodeficiency Common Variable: 2 people, 7.69%
  6. High Blood Cholesterol: 2 people, 7.69%
  7. Erection Problems: 2 people, 7.69%
  8. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Salonpas and Metformin?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Salonpas and Metformin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Salonpas:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Metformin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Salonpas and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Metformin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on menthol; methyl salicylate and metformin hydrochloride (the active ingredients of Salonpas and Metformin, respectively), and Salonpas and Metformin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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