Sancuso and Benadryl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sancuso (granisetron) and Benadryl (diphenhydramine hydrochloride). Common drug interactions include nausea among females and deep vein thrombosis among males.

The phase IV clinical study analyzes what interactions people have when they take Sancuso and Benadryl. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Sancuso?

Sancuso has active ingredients of granisetron. eHealthMe is studying from 1,765 Sancuso users. Check the latest studies of Sancuso.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,954 Benadryl users. Check the latest studies of Benadryl.

On Jul, 27, 2026

22 people who take Sancuso and Benadryl together, and have interactions are studied.

What are the common drug interactions of Sancuso and Benadryl, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Chest pain
Abdominal discomfort
Dehydration (dryness resulting from the removal of water)
Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)
Rash
Arthralgia (joint pain)
Alopecia (absence of hair from areas of the body)
Back pain
Fatigue (feeling of tiredness)

male:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Drug ineffective
Vomiting
Engraftment syndrome (inflammatory condition during neutrophil recovery after hematopoietic stem cell transplantation)
Pneumonia
Anaphylactic reaction (serious allergic reaction)
Dehydration (dryness resulting from the removal of water)
Nausea (feeling of having an urge to vomit)
Pancreatic carcinoma (pancreatic cancer)
Renal failure acute (rapid kidney dysfunction)

What are the common drug interactions of Sancuso and Benadryl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal discomfort
Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)
Nausea (feeling of having an urge to vomit)
Rash
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Muscle twitching
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arthralgia (joint pain)
Chest pain

40-49:

Dehydration (dryness resulting from the removal of water)
Chest pain
Pyrexia (fever)
Nausea (feeling of having an urge to vomit)
Renal failure acute (rapid kidney dysfunction)
Vomiting

50-59:

Alopecia (absence of hair from areas of the body)
Anaphylactic reaction (serious allergic reaction)
Mastitis (inflammation of breast)
Urticaria (rash of round, red welts on the skin that itch intensely)

60+:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Drug ineffective
Bradyphrenia (neurological term referring to the slowness of thought common to many disorders of the brain)
Burning sensation
Coronary arterial stent insertion
Cough
Death
Dyspnoea (difficult or laboured respiration)
Erythema (redness of the skin)
Fatigue (feeling of tiredness)

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 6 people, 27.27%
Pain: 4 people, 18.18%
Breast Cancer: 4 people, 18.18%
Multiple Myeloma (cancer of the plasma cells): 3 people, 13.64%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 3 people, 13.64%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 13.64%
Mouth Ulcers: 2 people, 9.09%
Iron Deficiency Anaemia: 2 people, 9.09%
Insomnia (sleeplessness): 2 people, 9.09%
Ovarian Cysts (fluid filled sacs of the ovary): 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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