Savella and Actos drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Savella (milnacipran hydrochloride) and Actos (pioglitazone hydrochloride). Common drug interactions include tremor among females and muscular weakness among males.

The phase IV clinical study analyzes what interactions people have when they take Savella and Actos. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Savella?

Savella has active ingredients of milnacipran hydrochloride. It is often used in fibromyalgia. eHealthMe is studying from 7,529 Savella users. Check the latest studies of Savella.

What is Actos?

Actos has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 49,754 Actos users. Check the latest studies of Actos.

On Jul, 06, 2026

22 people who take Savella and Actos together, and have interactions are studied.

What are the common drug interactions of Savella and Actos, by gender? *:

female:

Tremor (trembling or shaking movements in one or more parts of your body)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Palpitations (feelings or sensations that your heart is pounding or racing)
Pruritus (severe itching of the skin)
Skin cancer
Urinary tract infection
Blood pressure increased
Fatigue (feeling of tiredness)
Heart rate increased
Adverse drug reaction

male:

Muscular weakness (muscle weakness)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Myalgia (muscle pain)
Asthma
Dysuria (painful or difficult urination)
Urinary retention (the inability to completely or partially empty the bladder)

What are the common drug interactions of Savella and Actos, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Dyspnoea (difficult or laboured respiration)
Palpitations (feelings or sensations that your heart is pounding or racing)
Tremor (trembling or shaking movements in one or more parts of your body)
Bedridden
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Cystitis (inflammation of the wall of the bladder)
Device related infection
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Erythema (redness of the skin)

50-59:

Dizziness
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Skin cancer
Blood pressure increased
Heart rate increased
Adverse drug reaction
Chest pain
Constipation
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)

60+:

Chronic kidney disease
Pruritus (severe itching of the skin)
Renal failure (kidney dysfunction)
Drug hypersensitivity
Dysuria (painful or difficult urination)
Erythema (redness of the skin)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nausea (feeling of having an urge to vomit)
Nephrogenic anaemia (anaemia due to kidney disease)
Urinary retention (the inability to completely or partially empty the bladder)

What are the existing conditions these people have? *

High Blood Cholesterol: 10 people, 45.45%
Depression: 6 people, 27.27%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 22.73%
Thyroid Diseases: 4 people, 18.18%
Insomnia (sleeplessness): 3 people, 13.64%
Stress And Anxiety: 3 people, 13.64%
Pain: 3 people, 13.64%
Cardiac Disorder: 2 people, 9.09%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 2 people, 9.09%
Herpes Virus Infection: 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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