Norflex and Glucophage drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Norflex (orphenadrine citrate) and Glucophage (metformin hydrochloride). Common drug interactions include arthropathy among females and insomnia among males.

The phase IV clinical study analyzes what interactions people have when they take Norflex and Glucophage. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Norflex?

Norflex has active ingredients of orphenadrine citrate. It is often used in muscle spasms. eHealthMe is studying from 1,951 Norflex users. Check the latest studies of Norflex.

What is Glucophage?

Glucophage has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 60,851 Glucophage users. Check the latest studies of Glucophage.

On Jul, 06, 2026

29 people who take Norflex and Glucophage together, and have interactions are studied.

Norflex and Glucophage drug interactions.

What are the common drug interactions of Norflex and Glucophage, by gender? *:

female:

Arthropathy
Asthma
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Bipolar disorder (mood disorder)
Blood cholesterol increased
Cardiac failure congestive
Cellulitis (infection under the skin)
Chest pain
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)

male:

Insomnia (sleeplessness)
Diarrhoea
Nausea (feeling of having an urge to vomit)
Nervousness
Vomiting
Weight decreased
Diabetes mellitus inadequate control
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Renal failure (kidney dysfunction)
Anaemia (lack of blood)

What are the common drug interactions of Norflex and Glucophage, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Impaired work ability
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)

40-49:

Anaemia (lack of blood)
Cardiac failure
Gangrene (body tissue dies)
Hepatic failure (liver failure)
Hyperglycaemia (high blood sugar)
Obesity (having too much body fat)
Renal failure (kidney dysfunction)
Respiratory failure (inadequate gas exchange by the respiratory system)

50-59:

Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Cellulitis (infection under the skin)
Diarrhoea
Insomnia (sleeplessness)
Chest pain
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Hyperhidrosis (abnormally increased sweating)
Intervertebral disc protrusion (spinal disc protrusion)
Schizophrenia (a mental disorder characterized by a breakdown of thought processes)
Weight decreased

60+:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)
Aortic arteriosclerosis (hardening of the aortic arteries)
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Arthropathy
Asthma
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Bipolar disorder (mood disorder)
Blood cholesterol increased

What are the existing conditions these people have? *

Pain: 5 people, 17.24%
Procedural Pain: 3 people, 10.34%
Heart Rate Irregular: 3 people, 10.34%
Type 2 Diabetes: 2 people, 6.90%

* Approximation only. Some reports may have incomplete information.

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