Savella and Lactulose drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Savella (milnacipran hydrochloride) and Lactulose (lactulose). Common drug interactions include headache among females and autoimmune disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Savella and Lactulose. It is created by eHealthMe based on reports of 51 people who take the same drugs from the FDA, and is updated regularly.

What is Savella?

Savella has active ingredients of milnacipran hydrochloride. It is often used in fibromyalgia. eHealthMe is studying from 7,529 Savella users. Check the latest studies of Savella.

What is Lactulose?

Lactulose has active ingredients of lactulose. It is often used in constipation. eHealthMe is studying from 46,960 Lactulose users. Check the latest studies of Lactulose.

On Jul, 18, 2026

51 people who take Savella and Lactulose together, and have interactions are studied.

Savella and Lactulose drug interactions.

What are the common drug interactions of Savella and Lactulose, by gender? *:

female:

Headache (pain in head)
Fatigue (feeling of tiredness)
Drug ineffective
Back pain
Chronic kidney disease
Bipolar ii disorder (characterized by at least one episode of hypomania and at least one episode of major depression)
General physical health deterioration (weak health status)
Suicidal ideation
Borderline personality disorder
Cervical spinal stenosis (narrowing of the spinal canal in the neck)

male:

Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
Fatigue (feeling of tiredness)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Loss of consciousness
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Spinal fracture (fracture in one of vertebrae)
Suicidal ideation
Chronic kidney disease
Gout (uric acid crystals building up in the body)
Renal failure (kidney dysfunction)

What are the common drug interactions of Savella and Lactulose, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Aerophagia (excessive air swallowing)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Enuresis (repeated inability to control urination)
Influenza

40-49:

Drug ineffective
Back pain
Bipolar ii disorder (characterized by at least one episode of hypomania and at least one episode of major depression)
General physical health deterioration (weak health status)
Suicidal ideation
Borderline personality disorder
Cervical spinal stenosis (narrowing of the spinal canal in the neck)
Intervertebral disc protrusion (spinal disc protrusion)
Myalgia (muscle pain)
Fall

50-59:

Headache (pain in head)
Fatigue (feeling of tiredness)
Anaemia (lack of blood)
Cardiac arrest
Chronic kidney disease
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Sepsis (a severe blood infection that can lead to organ failure and death)
Back pain
Renal injury (kidney injury)
Surgery

60+:

Fatigue (feeling of tiredness)
Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
Asthenia (weakness)
Balance disorder
Gout (uric acid crystals building up in the body)
Nephrogenic anaemia (anaemia due to kidney disease)
Perineal infection
Renal injury (kidney injury)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Somnolence (a state of near-sleep, a strong desire for sleep)

What are the existing conditions these people have? *

Pain: 20 people, 39.22%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 20 people, 39.22%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 15 people, 29.41%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 17.65%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 9 people, 17.65%
Stress And Anxiety: 8 people, 15.69%
Asthma: 7 people, 13.73%
Depression: 7 people, 13.73%
Sleep Disorder: 6 people, 11.76%
High Blood Cholesterol: 6 people, 11.76%

* Approximation only. Some reports may have incomplete information.

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