Savella and Methotrexate sodium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Savella (milnacipran hydrochloride) and Methotrexate sodium (methotrexate sodium). Common drug interactions include drug hypersensitivity among females.

The phase IV clinical study analyzes what interactions people have when they take Savella and Methotrexate sodium. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Savella?

Savella has active ingredients of milnacipran hydrochloride. It is often used in fibromyalgia. eHealthMe is studying from 7,529 Savella users. Check the latest studies of Savella.

What is Methotrexate sodium?

Methotrexate sodium has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 97,679 Methotrexate sodium users. Check the latest studies of Methotrexate sodium.

On Jul, 07, 2026

23 people who take Savella and Methotrexate sodium together, and have interactions are studied.

Savella and Methotrexate sodium drug interactions.

What are the common drug interactions of Savella and Methotrexate Sodium, by gender? *:

female:

Drug hypersensitivity
Drug ineffective
Lung disorder (lung disease)
Mood altered (changes in mood)
Muscle tightness
Myalgia (muscle pain)
Peripheral swelling
Rash
Reading disorder (problem in areas of the brain that help interpret language)
Weight increased

male:

n/a

What are the common drug interactions of Savella and Methotrexate Sodium, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Arthralgia (joint pain)
Chills (felling of cold)
Migraine (headache)
Oedema peripheral (superficial swelling)
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
Throat irritation

50-59:

Drug hypersensitivity
Anaphylactic reaction (serious allergic reaction)
Blood glucose increased
Chest pain
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Hypoxia (low oxygen in tissues)
Infusion related reaction

60+:

Drug hypersensitivity
Reading disorder (problem in areas of the brain that help interpret language)
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Glaucoma (increased fluid pressure in the eye with vision loss)
Joint swelling
Leukopenia (less number of white blood cells in blood)
White blood cell count decreased
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Arthralgia (joint pain)

What are the existing conditions these people have? *

Pain: 5 people, 21.74%
Peripheral Swelling: 3 people, 13.04%
Depression: 3 people, 13.04%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 2 people, 8.70%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 8.70%
Cardiac Disorder: 2 people, 8.70%
Affective Disorder (mental disorder): 2 people, 8.70%
Abdominal Pain Upper: 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

Do you take Savella and Methotrexate sodium?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously