Se and Msm drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Se (selenium) and Msm (methylsulfonylmethane). Common drug interactions include uterine haemorrhage among females and vision blurred among males.

The phase IV clinical study analyzes what interactions people have when they take Se and Msm. It is created by eHealthMe based on reports of 37 people who take the same drugs from the FDA, and is updated regularly.

What is Se?

Se has active ingredients of selenium. eHealthMe is studying from 5,604 Se users. Check the latest studies of Se.

What is Msm?

Msm has active ingredients of methylsulfonylmethane. It is often used in joint pain. eHealthMe is studying from 1,210 Msm users. Check the latest studies of Msm.



On Jul, 09, 2026

37 people who take Se and Msm together, and have interactions are studied.

Se and Msm drug interactions.

What are the common drug interactions of Se and Msm, by gender? *:

female:

  1. Uterine haemorrhage (uterine bleeding)
  2. Weight decreased
  3. White blood cell count decreased
  4. Weight increased
  5. Complex regional pain syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet))
  6. Initial insomnia (feeling of inadequate or poor-quality sleep)
  7. Anaemia (lack of blood)
  8. Fatigue (feeling of tiredness)
  9. Gastric ulcer haemorrhage (bleeding ulcer of stomach)
  10. Gastrointestinal disorder (functional problems of gastrointestinal tract)

male:

  1. Vision blurred
  2. Body height decreased
  3. Blood pressure increased
  4. Cataract (clouding of the lens inside the eye)
  5. Chest discomfort
  6. Death
  7. Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
  8. Diarrhoea
  9. Dry eye (lack of adequate tears)
  10. Dry mouth

What are the common drug interactions of Se and Msm, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Weight increased
  2. Polycythaemia vera (blood disorder in which the bone marrow makes too many red blood cells)
  3. Uterine haemorrhage (uterine bleeding)

50-59:

  1. Anxiety
  2. Bone pain
  3. Burning sensation
  4. Contrast media reaction (reaction associated with the use of intravenous contrast material during radiology)
  5. Cystitis (inflammation of the wall of the bladder)
  6. Depression
  7. Drug screen positive
  8. Eye disorder
  9. Gastrointestinal disorder (functional problems of gastrointestinal tract)
  10. Insomnia (sleeplessness)

60+:

  1. Vision blurred
  2. Body height decreased
  3. Bladder disorder
  4. Blepharospasm (any abnormal contraction or twitch of the eyelid)
  5. Blood albumin decreased
  6. Blood creatinine decreased
  7. Blood pressure increased
  8. Cataract (clouding of the lens inside the eye)
  9. Chest discomfort
  10. Death

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 18.92%
  2. Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 8.11%
  3. Sleep Disorder: 2 people, 5.41%
  4. Pulmonary Embolism (blockage of the main artery of the lung): 2 people, 5.41%
  5. Pain: 2 people, 5.41%
  6. Neuralgia (pain in one or more nerves): 2 people, 5.41%
  7. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 5.41%
  8. Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 2 people, 5.41%
  9. Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 2 people, 5.41%

* Approximation only. Some reports may have incomplete information.

Do you take Se and Msm?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

  • Se (5,604 reports)
  • Msm (1,210 reports)

Browse all drug interactions of Se and Msm:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Se:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Msm:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Se and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Msm and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on selenium and methylsulfonylmethane (the active ingredients of Se and Msm, respectively), and Se and Msm (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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