Sectral and Prograf drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sectral (acebutolol hydrochloride) and Prograf (tacrolimus). Common drug interactions include pyrexia among females and cholestasis among males.

The phase IV clinical study analyzes what interactions people have when they take Sectral and Prograf. It is created by eHealthMe based on reports of 75 people who take the same drugs from the FDA, and is updated regularly.

What is Sectral?

Sectral has active ingredients of acebutolol hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 3,548 Sectral users. Check the latest studies of Sectral.

What is Prograf?

Prograf has active ingredients of tacrolimus. It is often used in kidney transplant. eHealthMe is studying from 42,230 Prograf users. Check the latest studies of Prograf.

On Jul, 10, 2026

75 people who take Sectral and Prograf together, and have interactions are studied.

What are the common drug interactions of Sectral and Prograf, by gender? *:

female:

Pyrexia (fever)
Acinetobacter bacteraemia (infection of bacteria)
Alopecia (absence of hair from areas of the body)
Anaemia (lack of blood)
Asthenia (weakness)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Calculus urinary (stone in urinary system)
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Dyspnoea exertional (breathlessness or shortness of breath)

male:

Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Sepsis (a severe blood infection that can lead to organ failure and death)
Photopsia (presence of perceived flashes of light)
Retinopathy hypertensive (acute damage to the retina of the eye due to high blood pressure)
Visual disturbance
Hallucination, visual (seeing things that aren't there)
Overdose
Abnormal sensation in eye
Electrocardiogram qt prolonged
Hepatitis (inflammation of the liver)

What are the common drug interactions of Sectral and Prograf, by age (0-1 to 60+)? *:

0-1:

Low birth weight baby
Pulmonary artery atresia (lungs artery absent)

2-9:

n/a

10-19:

Electrocardiogram qt prolonged
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Hyperkalaemia (damage to or disease of the kidney)

20-29:

Pancreatitis necrotising (inflammation of the pancreas cause death of tissue in pancreas)
Abdominal pain upper
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Back pain
Blood creatinine increased
Blood pressure decreased
Bone marrow toxicity (decrease in cells responsible for providing immunity, carrying oxygen, and those responsible for normal blood clotting)
Candidiasis (candidiasis or thrush is a fungal infection)
Cough
General physical health deterioration (weak health status)

30-39:

Overdose
Acinetobacter bacteraemia (infection of bacteria)
Alopecia (absence of hair from areas of the body)
Anaemia (lack of blood)
Asthenia (weakness)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Calculus urinary (stone in urinary system)
Cough
Dehydration (dryness resulting from the removal of water)
Diarrhoea

40-49:

Pneumonia
Back pain
Sepsis (a severe blood infection that can lead to organ failure and death)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Ventricular fibrillation (abnormally irregular heart rhythm)
Metabolic encephalopathy (disorder or disease of the brain due to the body's disability to use energy)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Peliosis hepatis (randomly distributed multiple blood-filled cavities throughout the liver)
Transplant rejection (a transplant material is not worked)
Immunosuppressant drug level decreased

50-59:

Multiple drug overdose intentional
Neuralgia (pain in one or more nerves)
Optic atrophy (the loss of a proportion of optic disc nerve fibres)
Optic nerve injury
Optic neuritis (optic nerve inflammation)
Pyelonephritis (inflammation of kidney caused by bacteria)
Pyelonephritis acute (sudden inflammation of kidney caused by bacteria)
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)
Sleep disorder

60+:

Gastrointestinal disorder (functional problems of gastrointestinal tract)
Hepatic necrosis (large portions of liver die off due to severe liver disease)
Drug toxicity
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Metabolic encephalopathy (disorder or disease of the brain due to the body's disability to use energy)
Nosocomial infection (infection from hospital)
Renal failure chronic (long lasting kidney dysfunction)
Confusional state
Photopsia (presence of perceived flashes of light)
Retinopathy hypertensive (acute damage to the retina of the eye due to high blood pressure)

What are the existing conditions these people have? *

Immunodeficiency Disorders: 20 people, 26.67%
Back Pain: 15 people, 20.00%
Infection: 14 people, 18.67%
Urinary Tract Infection: 13 people, 17.33%
Pain In Extremity: 13 people, 17.33%
Nausea (feeling of having an urge to vomit): 13 people, 17.33%
General Symptom: 13 people, 17.33%
Dizziness: 13 people, 17.33%
Cardiac Disorder: 13 people, 17.33%
Fatigue (feeling of tiredness): 12 people, 16.00%

* Approximation only. Some reports may have incomplete information.

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