Semglee and Trulicity drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Semglee (insulin glargine) and Trulicity (dulaglutide). Common drug interactions include blood glucose increased among females and headache among males.

The phase IV clinical study analyzes what interactions people have when they take Semglee and Trulicity. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Semglee?

Semglee has active ingredients of insulin glargine. eHealthMe is studying from 1,750 Semglee users. Check the latest studies of Semglee.

What is Trulicity?

Trulicity has active ingredients of dulaglutide. It is often used in weight loss. eHealthMe is studying from 77,529 Trulicity users. Check the latest studies of Trulicity.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

32 people who take Semglee and Trulicity together, and have interactions are studied.

Semglee and Trulicity drug interactions.

What are the common drug interactions of Semglee and Trulicity, by gender? *:

female:

Blood glucose increased
Drug ineffective
Visual impairment
Weight increased
Abdominal pain
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)
Dizziness
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Adnexa uteri cyst (ovarian cysts)

male:

Headache (pain in head)
Injection site hypertrophy (enlargement of an organ or tissue from the increase in size of its cells at injection site)
Somnolence (a state of near-sleep, a strong desire for sleep)
Surgery
Vision blurred
Weight increased
Fatigue (feeling of tiredness)
Death
Eye discharge
Generalised oedema (swelling all over the body)

What are the common drug interactions of Semglee and Trulicity, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Weight increased
Adnexa uteri cyst (ovarian cysts)
Device expulsion
Hypersensitivity

60+:

Blood glucose increased
Visual impairment
Injection site hypertrophy (enlargement of an organ or tissue from the increase in size of its cells at injection site)
Eye discharge
Headache (pain in head)
Vision blurred

What are the existing conditions these people have? *

Type 2 Diabetes: 16 people, 50.00%
Diabetes: 4 people, 12.50%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 6.25%
High Blood Pressure: 2 people, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Semglee and Trulicity?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously