Senna and Duragesic-50 drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Senna (senna) and Duragesic-50 (fentanyl). Common drug interactions include decreased appetite among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Senna and Duragesic-50. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Senna?

Senna has active ingredients of senna. It is often used in constipation. eHealthMe is studying from 37,302 Senna users. Check the latest studies of Senna.

What is Duragesic-50?

Duragesic-50 has active ingredients of fentanyl. It is often used in pain. eHealthMe is studying from 733 Duragesic-50 users. Check the latest studies of Duragesic-50.

On Jul, 13, 2026

12 people who take Senna and Duragesic-50 together, and have interactions are studied.

Senna and Duragesic-50 drug interactions.

What are the common drug interactions of Senna and Duragesic-50, by gender? *:

female:

Decreased appetite
Dental caries
Depression
Dry mouth
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Neuropathy peripheral (surface nerve damage)
Oedema peripheral (superficial swelling)
Onychomycosis (fungal infection of the nail)
Osteomyelitis (infection of bone)

male:

Anxiety
Injury
Deformity (disfigurement)
Depression
Discomfort
Emotional distress
Failure to thrive (inadequate weight gain and physical growth in children)
Haematochezia (passage of stools containing blood)
Hypophagia (reduced food intake)
Inguinal hernia (hernia in which a loop of intestine enters the inguinal canal; the most common type of hernia in males)

What are the common drug interactions of Senna and Duragesic-50, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Light chain analysis increased
Mucosal inflammation (infection of mucous membrane)
Myelitis transverse (a neurological condition consisting of an inflammatory process of the spinal cord)
Neoplasm malignant (cancer tumour)
Neuralgia (pain in one or more nerves)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteoporosis (bones weak and more likely to break)
Pleural fibrosis (formation of fibrous tissue in lung)
Post laminectomy syndrome

60+:

Anxiety
Asthenia (weakness)
Cellulitis (infection under the skin)
Cerebral disorder (brain disease)
Cervical spinal stenosis (narrowing of the spinal canal in the neck)
Chromatopsia (visual defect in which colourless objects appear to be tinged with colour)
Colonic polyp (extra part of colon tissue grow in intestine)
Confusional state
Conjunctivitis (pink eye)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 4 people, 33.33%
Skin Ulcer: 2 people, 16.67%
Osteoporosis (bones weak and more likely to break): 2 people, 16.67%
Haemorrhoids (a swollen vein or group of veins in the region of the anus): 2 people, 16.67%
Diabetes: 2 people, 16.67%
Thyroid Diseases: 1 person, 8.33%
Prostate Cancer: 1 person, 8.33%
Neck Pain: 1 person, 8.33%
Muscle Spasms (muscle contraction): 1 person, 8.33%
High Blood Cholesterol: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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