Sennosides and Pyrazinamide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sennosides (senna) and Pyrazinamide (pyrazinamide). Common drug interactions include alanine aminotransferase increased among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Sennosides and Pyrazinamide. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Sennosides?

Sennosides has active ingredients of senna. It is often used in constipation. eHealthMe is studying from 8,247 Sennosides users. Check the latest studies of Sennosides.

What is Pyrazinamide?

Pyrazinamide has active ingredients of pyrazinamide. It is often used in tuberculosis. eHealthMe is studying from 10,062 Pyrazinamide users. Check the latest studies of Pyrazinamide.

On Jul, 14, 2026

12 people who take Sennosides and Pyrazinamide together, and have interactions are studied.

Sennosides and Pyrazinamide drug interactions.

What are the common drug interactions of Sennosides and Pyrazinamide, by gender? *:

female:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood bilirubin increased
Decreased appetite
Hepatitis (inflammation of the liver)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Peripheral sensory neuropathy (damage to one or more of your peripheral nerves)
Pneumatosis intestinalis (air or gas in an intestine)

male:

Nausea (feeling of having an urge to vomit)
Acute myocardial infarction (acute heart attack)
Pneumonia
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)
Sleep disorder
Tuberculous pleurisy (an inflammation of lung covering plura by mycobacterium tuberculosis)
Asthenia (weakness)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Electrocardiogram qt prolonged

What are the common drug interactions of Sennosides and Pyrazinamide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Hepatitis (inflammation of the liver)
Nausea (feeling of having an urge to vomit)
Pneumatosis intestinalis (air or gas in an intestine)
Pneumonia
Tuberculous pleurisy (an inflammation of lung covering plura by mycobacterium tuberculosis)
Asthenia (weakness)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Electrocardiogram qt prolonged
Hepatotoxicity (chemical-driven liver damage)
Hyperuricaemia (level of uric acid in the blood that is abnormally high)

What are the existing conditions these people have? *

Pulmonary Tuberculosis (lungs tuberculosis): 5 people, 41.67%
Anaplastic Thyroid Cancer (thyroid cancer which has a very poor prognosis): 2 people, 16.67%
Hiv Infection: 2 people, 16.67%
Pneumonia Bacterial (pneumonia associated with bacterial infection): 2 people, 16.67%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 1 person, 8.33%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 1 person, 8.33%
Depression: 1 person, 8.33%
Gastritis - Chronic (long lasting inflammation of stomach): 1 person, 8.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 8.33%
Hepatic Function Abnormal: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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