Seroquel and Promacta drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Seroquel (quetiapine fumarate) and Promacta (eltrombopag olamine). Common drug interactions include death among females and mental disorder among males.
The phase IV clinical study analyzes what interactions people have when they take Seroquel and Promacta. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.
What is Seroquel?
Seroquel has active ingredients of quetiapine fumarate. It is often used in bipolar disorder. eHealthMe is studying from 120,285 Seroquel users. Check the latest studies of Seroquel.
What is Promacta?
Promacta has active ingredients of eltrombopag olamine. It is often used in idiopathic thrombocytopenic purpura (itp). eHealthMe is studying from 17,758 Promacta users. Check the latest studies of Promacta.
19 people who take Seroquel and Promacta together, and have interactions are studied.

What are the common drug interactions of Seroquel and Promacta, by gender? *:
female:
- Death
- Hyperaesthesia
- Hypoaesthesia (reduced sense of touch or sensation)
- Multi-organ failure (multisystem organ failure)
- Muscle disorder (muscle disease)
- Pain in extremity
- Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
- Platelet count decreased
- Sensation of blood flow
- Vision blurred
male:
- Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
What are the common drug interactions of Seroquel and Promacta, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
n/a
40-49:
- Confusional state
- Disorientation (disability in which the senses of time, direction, and recognition of people and places)
- Full blood count decreased
- Platelet count decreased
50-59:
- Drug ineffective
- Anaemia (lack of blood)
- Sepsis (a severe blood infection that can lead to organ failure and death)
- Septic encephalopathy (disorder or disease of the brain due to blood infection with bacteria)
60+:
- Adverse drug reaction
- Adverse event
- Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
- Sensation of blood flow
- Vision blurred
- Abdominal pain upper
- Confusional state
- Diarrhoea
- Disorientation (disability in which the senses of time, direction, and recognition of people and places)
- Flatulence (flatus expelled through the anus)
What are the existing conditions these people have? *
- Idiopathic Thrombocytopenic Purpura (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting): 3 people, 15.79%
- Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 3 people, 15.79%
- Thrombocytopenia (decrease of platelets in blood): 1 person, 5.26%
- Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 5.26%
- Platelet Disorder: 1 person, 5.26%
- Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 1 person, 5.26%
- Mania (a state of abnormally elevated or irritable mood): 1 person, 5.26%
- Lupus Nephritis (a chronic inflammatory autoimmune disorder that may affect kidney tissue): 1 person, 5.26%
- Insomnia (sleeplessness): 1 person, 5.26%
- Depression: 1 person, 5.26%
* Approximation only. Some reports may have incomplete information.
Do you take Seroquel and Promacta?
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Seroquel and Promacta:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Seroquel:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Promacta:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Seroquel and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Promacta and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Mati?, K., & Pele?, A. M. , "Drug-induced toxic hepatitis associated with the combination of quetiapine and fluphenazine: A case report", The European Journal of Psychiatry, 2018 Jan .
- Shah Z, Londhe V, "Influence of various media on the dissolution profiles of immediate-release quetiapine tablets in India", Dissolution Technologies, 2016 Feb .
- Mati?, K., & Pele?, A. M. , "Drug-induced toxic hepatitis associated with the combination of quetiapine and fluphenazine: A case report", The European Journal of Psychiatry, 2018 Jan .
- Shah Z, Londhe V, "Influence of various media on the dissolution profiles of immediate-release quetiapine tablets in India", Dissolution Technologies, 2016 Feb .
How the study uses the data?
The study uses data from the FDA. It is based on quetiapine fumarate and eltrombopag olamine (the active ingredients of Seroquel and Promacta, respectively), and Seroquel and Promacta (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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