Seroquel and Silvadene drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Seroquel (quetiapine fumarate) and Silvadene (silver sulfadiazine). Common drug interactions include dysuria among females and anhedonia among males.
The phase IV clinical study analyzes what interactions people have when they take Seroquel and Silvadene. It is created by eHealthMe based on reports of 37 people who take the same drugs from the FDA, and is updated regularly.
What is Seroquel?
Seroquel has active ingredients of quetiapine fumarate. It is often used in bipolar disorder. eHealthMe is studying from 120,285 Seroquel users. Check the latest studies of Seroquel.
What is Silvadene?
Silvadene has active ingredients of silver sulfadiazine. eHealthMe is studying from 1,161 Silvadene users. Check the latest studies of Silvadene.
37 people who take Seroquel and Silvadene together, and have interactions are studied.

What are the common drug interactions of Seroquel and Silvadene, by gender? *:
female:
- Dysuria (painful or difficult urination)
- Fungal infection
- Headache (pain in head)
- Hypoxia (low oxygen in tissues)
- Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
- Oedema peripheral (superficial swelling)
- Pyrexia (fever)
- Tearfulness (excess tearing)
- Abdominal distension
- Alcohol use
male:
- Anhedonia (inability to experience pleasure from activities usually found enjoyable)
- Anxiety
- Bone loss
- Chronic kidney disease
- Osteoarthritis (a joint disease caused by cartilage loss in a joint)
- Osteonecrosis (death of bone)
- Renal failure (kidney dysfunction)
- Death
- Retinal tear
- Acute psychosis (period of mentally unstable behaviour)
What are the common drug interactions of Seroquel and Silvadene, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
- Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
- Diabetes mellitus inadequate control
- Diabetic gastroparesis (paralysis of the muscles of the stomach caused by diabetes)
- Type 1 diabetes mellitus
- Acute psychosis (period of mentally unstable behaviour)
- Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
- Cellulitis (infection under the skin)
- Contusion (a type of hematoma of tissue in which capillaries)
- Diabetic foot infection
- Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
40-49:
- Chronic kidney disease
- Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
- Oedema peripheral (superficial swelling)
- Oesophageal oedema (swelling of oesophagus)
50-59:
- Hyperglycaemia (high blood sugar)
- Type 2 diabetes mellitus
- Anhedonia (inability to experience pleasure from activities usually found enjoyable)
- Anxiety
- Bone density decreased
- Bone loss
- Chondropathy (disease of the cartilage)
- Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
- Emotional distress
- Gait disturbance
60+:
- Pancreatitis acute (sudden inflammation of pancreas)
- Chronic kidney disease
- Renal failure (kidney dysfunction)
- Arteriosclerosis (thickening and hardening of arteries)
- Death
What are the existing conditions these people have? *
- Pain: 15 people, 40.54%
- Agitation (state of anxiety or nervous excitement): 5 people, 13.51%
- Hiv Infection: 4 people, 10.81%
- Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 10.81%
- Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 10.81%
- High Blood Cholesterol: 4 people, 10.81%
- Stress And Anxiety: 4 people, 10.81%
- Cardiac Disorder: 4 people, 10.81%
- Depression: 4 people, 10.81%
- Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 4 people, 10.81%
* Approximation only. Some reports may have incomplete information.
Do you take Seroquel and Silvadene?
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Seroquel and Silvadene:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Seroquel:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Silvadene:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Seroquel and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Silvadene and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Mati?, K., & Pele?, A. M. , "Drug-induced toxic hepatitis associated with the combination of quetiapine and fluphenazine: A case report", The European Journal of Psychiatry, 2018 Jan .
- Shah Z, Londhe V, "Influence of various media on the dissolution profiles of immediate-release quetiapine tablets in India", Dissolution Technologies, 2016 Feb .
- Mati?, K., & Pele?, A. M. , "Drug-induced toxic hepatitis associated with the combination of quetiapine and fluphenazine: A case report", The European Journal of Psychiatry, 2018 Jan .
- Shah Z, Londhe V, "Influence of various media on the dissolution profiles of immediate-release quetiapine tablets in India", Dissolution Technologies, 2016 Feb .
How the study uses the data?
The study uses data from the FDA. It is based on quetiapine fumarate and silver sulfadiazine (the active ingredients of Seroquel and Silvadene, respectively), and Seroquel and Silvadene (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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