Sertraline and Cevimeline drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sertraline (sertraline hydrochloride) and Cevimeline (cevimeline hydrochloride). Common drug interactions include tooth abscess among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Sertraline and Cevimeline. It is created by eHealthMe based on reports of 60 people who take the same drugs from the FDA, and is updated regularly.

What is Sertraline?

Sertraline has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 153,305 Sertraline users. Check the latest studies of Sertraline.

What is Cevimeline?

Cevimeline has active ingredients of cevimeline hydrochloride. It is often used in sjogren syndrome. eHealthMe is studying from 1,480 Cevimeline users. Check the latest studies of Cevimeline.

On Aug, 11, 2026

60 people who take Sertraline and Cevimeline together, and have interactions are studied.

Sertraline and Cevimeline drug interactions.

What are the common drug interactions of Sertraline and Cevimeline, by gender? *:

female:

Tooth abscess (pus formation in tooth)
Tooth fracture
Upper respiratory tract infection
Pain in extremity
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Infusion site discomfort
Infusion site pain
Multiple allergies (allergy to multiple agents)

male:

Asthenia (weakness)
Pneumonia
Alanine aminotransferase increased
Aortic valve stenosis (narrowing of the aortic valve)
Ascites (accumulation of fluid in the abdominal cavity)
Aspartate aminotransferase increased
Blood albumin decreased
Blood alkaline phosphatase increased
Blood lactic acid increased
Chest discomfort

What are the common drug interactions of Sertraline and Cevimeline, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Mania (a state of abnormally elevated or irritable mood)

40-49:

n/a

50-59:

Red blood cell count decreased
Rhinitis allergic (inflammation of the nasal airways due to allergy)
Skin ulcer
Tremor (trembling or shaking movements in one or more parts of your body)
Vocal cord polyp
Hypoaesthesia (reduced sense of touch or sensation)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Psoriasis (immune-mediated disease that affects the skin)
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)

60+:

Fall
Pneumonia
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Seasonal allergy (allergic condition due to certain season)
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Pleural effusion (water on the lungs)
Nausea (feeling of having an urge to vomit)
Pulmonary oedema (fluid accumulation in the lungs)
Fatigue (feeling of tiredness)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 10 people, 16.67%
Urinary Tract Infection: 5 people, 8.33%
Multiple Myeloma (cancer of the plasma cells): 5 people, 8.33%
Dry Mouth: 5 people, 8.33%
Insomnia (sleeplessness): 5 people, 8.33%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 5 people, 8.33%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 4 people, 6.67%
Muscle Spasms (muscle contraction): 3 people, 5.00%
Mental Disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 3 people, 5.00%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 3 people, 5.00%

* Approximation only. Some reports may have incomplete information.

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