Sertraline and Zelnorm drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sertraline (sertraline hydrochloride) and Zelnorm (tegaserod maleate). Common drug interactions include gastrooesophageal reflux disease among females and injury among males.

The phase IV clinical study analyzes what interactions people have when they take Sertraline and Zelnorm. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Sertraline?

Sertraline has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 153,304 Sertraline users. Check the latest studies of Sertraline.

What is Zelnorm?

Zelnorm has active ingredients of tegaserod maleate. eHealthMe is studying from 7,261 Zelnorm users. Check the latest studies of Zelnorm.

On Jul, 12, 2026

28 people who take Sertraline and Zelnorm together, and have interactions are studied.

Sertraline and Zelnorm drug interactions.

What are the common drug interactions of Sertraline and Zelnorm, by gender? *:

female:

Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Impaired gastric emptying
Muscle spasms (muscle contraction)
Renal failure (kidney dysfunction)
Anaemia (lack of blood)
Atelectasis (partial or complete collapse of the lung)
Bile duct stone
Blood cholesterol increased
Bone disorder
Bone fragmentation

male:

Injury
Pain
Bone disorder
Bone fragmentation
Bone marrow reticulin fibrosis (thickening and scarring of bone marrow reticulin)
Bone swelling
Cardiac failure congestive
Cellulitis (infection under the skin)
Chest pain
Dental caries

What are the common drug interactions of Sertraline and Zelnorm, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Abdominal distension
Benign neoplasm of spinal cord (benign (non-cancerous) tumours of the spinal cord)
Maternal exposure during pregnancy (use of substance during pregnancy)

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Pain
Skin exfoliation (removal of the oldest dead skin cells)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest pain
Epistaxis (bleed from the nose)
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Renal injury (kidney injury)
Syncope (loss of consciousness with an inability to maintain postural tone)

60+:

Nausea (feeling of having an urge to vomit)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Bile duct stone
Blood cholesterol increased
Bone disorder
Bone fragmentation
Bone marrow reticulin fibrosis (thickening and scarring of bone marrow reticulin)
Bone swelling
Cellulitis (infection under the skin)
Chest pain

What are the existing conditions these people have? *

Trismus (reduced opening of the jaws): 16 people, 57.14%
Multiple Myeloma (cancer of the plasma cells): 16 people, 57.14%
Insomnia (sleeplessness): 4 people, 14.29%
Chest Pain: 4 people, 14.29%
Diabetes: 3 people, 10.71%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 10.71%
High Blood Pressure: 3 people, 10.71%
Irritable Bowel Syndrome: 3 people, 10.71%
Impaired Gastric Emptying: 2 people, 7.14%
Cardiac Disorder: 2 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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