Serzone and Dexedrine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Serzone (nefazodone hydrochloride) and Dexedrine (dextroamphetamine sulfate). Common drug interactions include pancreatitis among females and hepatic failure among males.

The phase IV clinical study analyzes what interactions people have when they take Serzone and Dexedrine. It is created by eHealthMe based on reports of 44 people who take the same drugs from the FDA, and is updated regularly.

What is Serzone?

Serzone has active ingredients of nefazodone hydrochloride. It is often used in depression. eHealthMe is studying from 7,695 Serzone users. Check the latest studies of Serzone.

What is Dexedrine?

Dexedrine has active ingredients of dextroamphetamine sulfate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 4,735 Dexedrine users. Check the latest studies of Dexedrine.

On Jul, 11, 2026

44 people who take Serzone and Dexedrine together, and have interactions are studied.

Serzone and Dexedrine drug interactions.

What are the common drug interactions of Serzone and Dexedrine, by gender? *:

female:

Pancreatitis (inflammation of pancreas)
Alopecia (absence of hair from areas of the body)
Asthenia (weakness)
Drug ineffective
Vomiting
White blood cell count decreased
Abdominal pain
Abdominal pain lower
Abdominal pain upper
Amenorrhoea (absence of a menstrual period in a woman of reproductive age)

male:

Hepatic failure (liver failure)
Vomiting
Hepatitis fulminant (life-threatening condition defined by significantly impaired liver function)
Nausea (feeling of having an urge to vomit)
Abdominal pain upper
Alopecia (absence of hair from areas of the body)
Amblyopia (lazy eye)
Amyloidosis (a tumour within which amyloid is produced)
Anal fissure
Androgens decreased

What are the common drug interactions of Serzone and Dexedrine, by age (0-1 to 60+)? *:

0-1:

Blood triglycerides increased
Breast cancer
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Pancreatitis (inflammation of pancreas)

2-9:

Abdominal pain
Vomiting

10-19:

Dizziness
Amblyopia (lazy eye)
Dry eye (lack of adequate tears)
Eye pain
Myalgia (muscle pain)
Nausea (feeling of having an urge to vomit)
Photophobia (extreme sensitivity to light)

20-29:

n/a

30-39:

n/a

40-49:

Lip dry
Chills (felling of cold)
Dry mouth
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Muscle twitching
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Tremor (trembling or shaking movements in one or more parts of your body)
Hepatic failure (liver failure)
Alanine aminotransferase increased

50-59:

Menstrual disorder (disease of menstrual cycle)
Metrorrhagia (uterine bleeding at irregular intervals)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Renal atrophy (wasting of kidney)
Abdominal pain upper
Alopecia (absence of hair from areas of the body)
Amyloidosis (a tumour within which amyloid is produced)
Anal fissure
Androgens decreased
Aortic dilatation

60+:

Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Cardiac failure congestive
Pancreatitis (inflammation of pancreas)
Pancreatitis acute (sudden inflammation of pancreas)
Renal failure (kidney dysfunction)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Ejection fraction decreased (systolic heart failure)
Renal disorder (kidney disease)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)

What are the existing conditions these people have? *

Neuropathy Peripheral (surface nerve damage): 4 people, 9.09%
Muscle Aches (muscle pain): 3 people, 6.82%
Multiple Myeloma (cancer of the plasma cells): 3 people, 6.82%
Libido Decreased (loss of interest in sex): 3 people, 6.82%
High Blood Pressure: 3 people, 6.82%
Bone Disorder: 3 people, 6.82%
Anaemia (lack of blood): 3 people, 6.82%

* Approximation only. Some reports may have incomplete information.

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