Serzone and Gabitril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Serzone (nefazodone hydrochloride) and Gabitril (tiagabine hydrochloride). Common drug interactions include angle closure glaucoma among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Serzone and Gabitril. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Serzone?

Serzone has active ingredients of nefazodone hydrochloride. It is often used in depression. eHealthMe is studying from 7,695 Serzone users. Check the latest studies of Serzone.

What is Gabitril?

Gabitril has active ingredients of tiagabine hydrochloride. It is often used in epilepsy. eHealthMe is studying from 2,230 Gabitril users. Check the latest studies of Gabitril.

On Jul, 13, 2026

35 people who take Serzone and Gabitril together, and have interactions are studied.

What are the common drug interactions of Serzone and Gabitril, by gender? *:

female:

Angle closure glaucoma (term used for several ocular diseases that ultimately result in increased intraocular pressure (iop) and decreased visual acuity)
Asterixis (flapping tremor, or liver flap)
Balance disorder
Blepharitis (chronic inflammation of the eyelid)
Blindness transient (sudden loss of vision)
Borderline glaucoma
Cataract subcapsular (cataracts that affect the back of the lens)
Conjunctival cyst (thin-walled sac or vesicle that contains fluid in eye covering)
Conjunctivitis (pink eye)
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)

male:

Drug ineffective
Hyperhidrosis (abnormally increased sweating)
Crying
Diarrhoea
Disability
Disturbance in attention
Dizziness
Energy increased
Faeces discoloured
Mood swings (an extreme or rapid change in mood)

What are the common drug interactions of Serzone and Gabitril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Status epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure)
Muscle twitching
Tremor (trembling or shaking movements in one or more parts of your body)
Psychomotor retardation (motor mental retardation)
Asterixis (flapping tremor, or liver flap)
Balance disorder
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Dystonia (abnormal muscle tone)
Generalised non-convulsive epilepsy (epilepsy without convulsions)
Haemangioma acquired (noncancerous, abnormally dense collections of dilated small blood vessels that may occur in the skin or internal organs-acquired)

30-39:

Nervousness
Abdominal discomfort
Adverse drug reaction
Burning sensation
Chest discomfort
Ear pain
Gastritis (inflammation of stomach)
Hyperventilation
Nicotine dependence
Palpitations (feelings or sensations that your heart is pounding or racing)

40-49:

Tremor (trembling or shaking movements in one or more parts of your body)

50-59:

Hallucination, auditory (perceiving sounds without auditory stimulus)
Hyperhidrosis (abnormally increased sweating)
Limb injury
Nephritis interstitial (a kidney condition characterized by swelling in between the kidney tubules)
Overdose
Pain
Restlessness (not able to rest)
Suicide attempt
Affect lability (emotional incontinence)
Aggression

60+:

Chronic kidney disease
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Renal failure (kidney dysfunction)
Syncope (loss of consciousness with an inability to maintain postural tone)
Type 2 diabetes mellitus

What are the existing conditions these people have? *

Stress And Anxiety: 7 people, 20.00%
Sleep Disorder: 7 people, 20.00%
Psychotic Disorder: 6 people, 17.14%
Agitation (state of anxiety or nervous excitement): 6 people, 17.14%
Pain: 4 people, 11.43%
Bipolar Disorder (mood disorder): 4 people, 11.43%
Mood Swings (an extreme or rapid change in mood): 3 people, 8.57%
Insomnia (sleeplessness): 3 people, 8.57%
Quit Smoking: 2 people, 5.71%
Neuropathy Peripheral (surface nerve damage): 2 people, 5.71%

* Approximation only. Some reports may have incomplete information.

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