Serzone and Phenergan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Serzone (nefazodone hydrochloride) and Phenergan (promethazine hydrochloride). Common drug interactions include urinary tract infection among females and drug dependence among males.

The phase IV clinical study analyzes what interactions people have when they take Serzone and Phenergan. It is created by eHealthMe based on reports of 58 people who take the same drugs from the FDA, and is updated regularly.

What is Serzone?

Serzone has active ingredients of nefazodone hydrochloride. It is often used in depression. eHealthMe is studying from 7,695 Serzone users. Check the latest studies of Serzone.

What is Phenergan?

Phenergan has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 25,312 Phenergan users. Check the latest studies of Phenergan.

On Jul, 08, 2026

58 people who take Serzone and Phenergan together, and have interactions are studied.

Serzone and Phenergan drug interactions.

What are the common drug interactions of Serzone and Phenergan, by gender? *:

female:

Urinary tract infection
Cough
Weight increased
Appetite decreased (decreased appetite occurs when you have a reduced desire to eat)
Cellulitis (infection under the skin)
Chest pain
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dyskinesia (abnormality or impairment of voluntary movement)
Fatigue (feeling of tiredness)
Hypotension (abnormally low blood pressure)

male:

Drug dependence
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Chest discomfort
Constipation
Contusion (a type of hematoma of tissue in which capillaries)
Hepatic failure (liver failure)
Hyperglycaemia (high blood sugar)
Hypoaesthesia (reduced sense of touch or sensation)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Tremor (trembling or shaking movements in one or more parts of your body)

What are the common drug interactions of Serzone and Phenergan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal pain
Blood in stool
Chest pain
Constipation
Diarrhoea
Dizziness
Drug ineffective
Headache (pain in head)
Melaena (the passage of black, tarry stools)
Pain in jaw

30-39:

Hyperglycaemia (high blood sugar)
Weakness
Appetite decreased (decreased appetite occurs when you have a reduced desire to eat)
Coma (state of unconsciousness lasting more than six hours)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Hypertension (high blood pressure)
Abdominal pain
Acute respiratory distress syndrome
Anoxia (low oxygen)
Blindness

40-49:

Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Dyskinesia (abnormality or impairment of voluntary movement)
Hypoaesthesia (reduced sense of touch or sensation)
Nephrolithiasis (calculi in the kidneys)
Oedema peripheral (superficial swelling)
Urinary tract infection
Back pain
Hepatic failure (liver failure)
Lethargy (tiredness)
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)

50-59:

Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Drug dependence
Dry mouth
Haematocrit decreased
Headache (pain in head)
Hyperkalaemia (damage to or disease of the kidney)
Hypoaesthesia (reduced sense of touch or sensation)
Hypokalaemia (low potassium)
Lethargy (tiredness)

60+:

Abdominal discomfort
Abdominal distension
Cardiogenic shock (inadequate circulation of blood)
Cardiomegaly (increased size of heart than normal)
Cardiomyopathy (weakening of the heart muscle)
Cardioversion
Chronic kidney disease
Conduction disorder (serious disorder of the heart not responses proper to impulses)
Congestive cardiomyopathy (weakening of heart muscle)
Constricted affect (limited affect)

What are the existing conditions these people have? *

Pain: 7 people, 12.07%
Headache (pain in head): 6 people, 10.34%
Insomnia (sleeplessness): 5 people, 8.62%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 8.62%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 6.90%
Bipolar Disorder (mood disorder): 4 people, 6.90%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 3 people, 5.17%
Irritable Bowel Syndrome: 3 people, 5.17%

* Approximation only. Some reports may have incomplete information.

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