Serzone and Restoril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Serzone (nefazodone hydrochloride) and Restoril (temazepam). Common drug interactions include dry mouth among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Serzone and Restoril. It is created by eHealthMe based on reports of 95 people who take the same drugs from the FDA, and is updated regularly.

What is Serzone?

Serzone has active ingredients of nefazodone hydrochloride. It is often used in depression. eHealthMe is studying from 7,695 Serzone users. Check the latest studies of Serzone.

What is Restoril?

Restoril has active ingredients of temazepam. It is often used in insomnia. eHealthMe is studying from 13,522 Restoril users. Check the latest studies of Restoril.

On Jul, 12, 2026

95 people who take Serzone and Restoril together, and have interactions are studied.

What are the common drug interactions of Serzone and Restoril, by gender? *:

female:

Dry mouth
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypotension (abnormally low blood pressure)
Nausea (feeling of having an urge to vomit)
Obesity (having too much body fat)
Pain in extremity
Type 2 diabetes mellitus
Abdominal pain
Alanine aminotransferase increased
Arthralgia (joint pain)

male:

Pain
Arthralgia (joint pain)
Bone disorder
General physical health deterioration (weak health status)
Injury
Neuralgia (pain in one or more nerves)
Osteonecrosis of jaw (death of bone of jaw)
Pain in jaw
Sinusitis (inflammation of sinus)
Wheezing (a high-pitched whistling sound made while you breath)

What are the common drug interactions of Serzone and Restoril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abnormal dreams
Agoraphobia (extreme or irrational fear of crowded spaces or enclosed public places)
Arthralgia (joint pain)
Back pain
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Confusional state
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Disturbance in attention
Dizziness

40-49:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Type 2 diabetes mellitus
Nephrotic syndrome (kidney disease with proteinuria, hypoalbuminemia, and oedema)
Hepatitis (inflammation of the liver)
Hypotension (abnormally low blood pressure)
Pain
Pancreatitis (inflammation of pancreas)
Weight decreased
Epistaxis (bleed from the nose)
Peripheral neuropathy (damage to nerves of the peripheral nervous system)

50-59:

Constipation
Dyspnoea (difficult or laboured respiration)
Abdominal pain upper
Anaemia (lack of blood)
Arthralgia (joint pain)
Diarrhoea
Dizziness
Emotional distress
Fatigue (feeling of tiredness)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

60+:

Anaemia (lack of blood)
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
General physical health deterioration (weak health status)
Hydrocele
Intervertebral disc degeneration (spinal disc degeneration)
Loss of consciousness
Mass
Mouth ulceration (mouth ulcers)
Neuralgia (pain in one or more nerves)

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 18 people, 18.95%
Pain: 13 people, 13.68%
Stress And Anxiety: 9 people, 9.47%
Sleep Disorder: 9 people, 9.47%
Bipolar Disorder (mood disorder): 6 people, 6.32%
Arrhythmias (irregular heartbeat): 5 people, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Serzone and Restoril?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously