Silybum and Zantac drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Silybum (milk thistle) and Zantac (ranitidine hydrochloride). Common drug interactions include nausea among females and allergic sinusitis among males.

The phase IV clinical study analyzes what interactions people have when they take Silybum and Zantac. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Silybum?

Silybum has active ingredients of milk thistle. eHealthMe is studying from 779 Silybum users. Check the latest studies of Silybum.

What is Zantac?

Zantac has active ingredients of ranitidine hydrochloride. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 434,161 Zantac users. Check the latest studies of Zantac.

On Jul, 20, 2026

19 people who take Silybum and Zantac together, and have interactions are studied.

What are the common drug interactions of Silybum and Zantac, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Blood pressure increased
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Fatigue (feeling of tiredness)
Headache (pain in head)
Hypotension (abnormally low blood pressure)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Pyrexia (fever)
Tumour pain
Visual impairment

male:

Allergic sinusitis
Disability
Limb discomfort (discomfort in leg)
Neuropathy peripheral (surface nerve damage)
Onychoclasis (breaking of the nails)
Pain
Post procedural haemorrhage (post procedural bleeding)
Renal cyst (kidney cyst)
Tremor (trembling or shaking movements in one or more parts of your body)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)

What are the common drug interactions of Silybum and Zantac, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Loss of consciousness
Pneumonia

40-49:

n/a

50-59:

Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Fatigue (feeling of tiredness)
Headache (pain in head)
Hypotension (abnormally low blood pressure)
Nausea (feeling of having an urge to vomit)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Pyrexia (fever)
Tumour pain

60+:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Back pain
Biliary adenoma (biliary tumour)
Body temperature decreased
Drug intolerance (drug sensitivity)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Lymphadenopathy (disease or enlargement of lymph nodes)
Neutropenia (an abnormally low number of neutrophils)
Thrombocytopenia (decrease of platelets in blood)
Burning sensation

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 12 people, 63.16%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 3 people, 15.79%
Cardiac Disorder: 3 people, 15.79%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 2 people, 10.53%
Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 10.53%
Bone Marrow Conditioning Regimen: 2 people, 10.53%
Allergic Sinusitis: 2 people, 10.53%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 1 person, 5.26%
Pain: 1 person, 5.26%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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