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Simcor and Lunesta drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Simcor (niacin; simvastatin) and Lunesta (eszopiclone). Common drug interactions include flushing among females and flushing among males.

The phase IV clinical study analyzes what interactions people have when they take Simcor and Lunesta. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Simcor?

Simcor has active ingredients of niacin; simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 11,604 Simcor users. Check the latest studies of Simcor.

What is Lunesta?

Lunesta has active ingredients of eszopiclone. It is often used in insomnia. eHealthMe is studying from 26,936 Lunesta users. Check the latest studies of Lunesta.

On Jul, 30, 2026

22 people who take Simcor and Lunesta together, and have interactions are studied.

Simcor and Lunesta drug interactions.

What are the common drug interactions of Simcor and Lunesta, by gender? *:

female:

  1. Flushing (the warm, red condition of human skin)
  2. Oral pain
  3. Pain
  4. Back pain
  5. Balance disorder
  6. Drug ineffective
  7. Excoriation (to tear or wear off the skin of)
  8. Fall
  9. Hand fracture
  10. Road traffic accident

male:

  1. Flushing (the warm, red condition of human skin)
  2. Abdominal discomfort
  3. Drug administration error
  4. Erythema (redness of the skin)
  5. Faeces discoloured
  6. Initial insomnia (feeling of inadequate or poor-quality sleep)
  7. Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)
  8. Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
  9. Pruritus (severe itching of the skin)
  10. Rectal haemorrhage (bleeding from anus)

What are the common drug interactions of Simcor and Lunesta, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Diarrhoea
  2. Pruritus (severe itching of the skin)
  3. Skin burning sensation

50-59:

  1. Flushing (the warm, red condition of human skin)
  2. Diarrhoea
  3. Chest pain
  4. Drug administration error
  5. Erythema (redness of the skin)
  6. Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
  7. Skin burning sensation

60+:

  1. Back pain
  2. Oral pain
  3. Chest injury
  4. Chest pain
  5. Contusion (a type of hematoma of tissue in which capillaries)
  6. Dry mouth
  7. Flushing (the warm, red condition of human skin)
  8. Night sweats (sweating in night)
  9. Pain in extremity
  10. Pruritus (severe itching of the skin)

What are the existing conditions these people have? *

  1. Osteoporosis (bones weak and more likely to break): 5 people, 22.73%
  2. Low Density Lipoprotein Increased (cholesterol increased in blood): 4 people, 18.18%
  3. High Density Lipoprotein Decreased: 4 people, 18.18%
  4. Constipation: 4 people, 18.18%
  5. Stress And Anxiety: 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Simcor and Lunesta?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Simcor and Lunesta:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Simcor:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Lunesta:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Simcor and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Lunesta and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on niacin; simvastatin and eszopiclone (the active ingredients of Simcor and Lunesta, respectively), and Simcor and Lunesta (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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