Simcor and Reclast drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Simcor (niacin; simvastatin) and Reclast (zoledronic acid). Common drug interactions include flushing among females and activities of daily living impaired among males.

The phase IV clinical study analyzes what interactions people have when they take Simcor and Reclast. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Simcor?

Simcor has active ingredients of niacin; simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 11,604 Simcor users. Check the latest studies of Simcor.

What is Reclast?

Reclast has active ingredients of zoledronic acid. It is often used in osteoporosis. eHealthMe is studying from 15,774 Reclast users. Check the latest studies of Reclast.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

12 people who take Simcor and Reclast together, and have interactions are studied.

What are the common drug interactions of Simcor and Reclast, by gender? *:

female:

Flushing (the warm, red condition of human skin)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Impaired healing
Abdominal discomfort
Foot fracture
Injection site haemorrhage (bleeding from injection site)
Injection site pain
Seasonal allergy (allergic condition due to certain season)
Feeling hot
Pruritus (severe itching of the skin)

male:

Activities of daily living impaired
Anaemia postoperative
Fracture nonunion (permanent failure of healing following a broken bone)
Gait disturbance
Groin pain
Hypoaesthesia (reduced sense of touch or sensation)
Impaired healing
Joint range of motion decreased (disease of joint movement)
Limb asymmetry (consistent task discrepancy between the two lower limbs)
Muscular weakness (muscle weakness)

What are the common drug interactions of Simcor and Reclast, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Activities of daily living impaired
Anaemia postoperative
Arthralgia (joint pain)
Bone pain
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Comminuted fracture (bone has broken into several pieces)
Fall
Femur fracture
Fracture delayed union (delayed cure of broken bone)
Fracture displacement

40-49:

n/a

50-59:

Abdominal discomfort
Foot fracture
Impaired healing
Injection site haemorrhage (bleeding from injection site)
Injection site pain
Seasonal allergy (allergic condition due to certain season)
Erythema (redness of the skin)
Feeling hot
Flushing (the warm, red condition of human skin)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

60+:

Flushing (the warm, red condition of human skin)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Anaemia postoperative
Arthralgia (joint pain)
Blood glucose decreased
Bone pain
Cardiac disorder
Cardiac failure congestive
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Dizziness

What are the existing conditions these people have? *

Depression: 3 people, 25.00%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 25.00%
Urinary Tract Infection: 2 people, 16.67%
Hyperlipidaemia (presence of excess lipids in the blood): 2 people, 16.67%
Diabetes: 2 people, 16.67%
Stress And Anxiety: 2 people, 16.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 16.67%
Arthropathy: 2 people, 16.67%
Migraine (headache): 2 people, 16.67%
High Blood Pressure: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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