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Simponi and Hydrodiuril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Simponi (golimumab) and Hydrodiuril (hydrochlorothiazide). Common drug interactions include drug ineffective among females.

The phase IV clinical study analyzes what interactions people have when they take Simponi and Hydrodiuril. It is created by eHealthMe based on reports of 64 people who take the same drugs from the FDA, and is updated regularly.

What is Simponi?

Simponi has active ingredients of golimumab. It is often used in rheumatoid arthritis. eHealthMe is studying from 86,328 Simponi users. Check the latest studies of Simponi.

What is Hydrodiuril?

Hydrodiuril has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 4,211 Hydrodiuril users. Check the latest studies of Hydrodiuril.

On Jul, 18, 2026

64 people who take Simponi and Hydrodiuril together, and have interactions are studied.

Simponi and Hydrodiuril drug interactions.

What are the common drug interactions of Simponi and Hydrodiuril, by gender? *:

female:

  1. Drug ineffective
  2. Fatigue (feeling of tiredness)
  3. Blood potassium decreased
  4. Erythema (redness of the skin)
  5. Ligament sprain (ligament stretched)
  6. Pruritus (severe itching of the skin)
  7. Rib fracture
  8. Transaminases increased
  9. Abdominal pain
  10. Diarrhoea

male:

n/a

What are the common drug interactions of Simponi and Hydrodiuril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Hypersensitivity
  2. Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)

50-59:

  1. Drug intolerance (drug sensitivity)
  2. Pain
  3. Drug hypersensitivity
  4. Constipation
  5. Hypersensitivity
  6. Iodine allergy
  7. Abdominal pain
  8. Diarrhoea
  9. Dizziness
  10. Fibromyalgia (a long-term condition which causes pain all over the body)

60+:

  1. Blood potassium decreased
  2. Erythema (redness of the skin)
  3. Ligament sprain (ligament stretched)
  4. Oedema (fluid collection in tissue)
  5. Pruritus (severe itching of the skin)
  6. Rib fracture
  7. Transaminases increased

What are the existing conditions these people have? *

  1. Hot Flush (sudden feelings of heat): 46 people, 71.88%
  2. Arthritis (form of joint disorder that involves inflammation of one or more joints): 4 people, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Simponi and Hydrodiuril?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Simponi and Hydrodiuril:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Simponi:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Hydrodiuril:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Simponi and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Hydrodiuril and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on golimumab and hydrochlorothiazide (the active ingredients of Simponi and Hydrodiuril, respectively), and Simponi and Hydrodiuril (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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