Aciphex and Opana drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aciphex (rabeprazole sodium) and Opana (oxymorphone hydrochloride). Common drug interactions include migraine among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Aciphex and Opana. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Aciphex?

Aciphex has active ingredients of rabeprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 25,301 Aciphex users. Check the latest studies of Aciphex.

What is Opana?

Opana has active ingredients of oxymorphone hydrochloride. It is often used in pain. eHealthMe is studying from 40,340 Opana users. Check the latest studies of Opana.

On Jul, 18, 2026

41 people who take Aciphex and Opana together, and have interactions are studied.

What are the common drug interactions of Aciphex and Opana, by gender? *:

female:

Migraine (headache)
Contusion (a type of hematoma of tissue in which capillaries)
Diarrhoea
Chronic kidney disease
Anxiety
Arthralgia (joint pain)
Asthma
Cauda equina syndrome (affecting the bundle of nerve roots)
Neck pain
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Blood glucose increased
Bone pain
Breakthrough pain
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Dependence
Gait disturbance
Infection
Malaise (a feeling of general discomfort or uneasiness)

What are the common drug interactions of Aciphex and Opana, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Abdominal pain upper
Contusion (a type of hematoma of tissue in which capillaries)
Diarrhoea
Dyspepsia (indigestion)
Gastrointestinal pain
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nausea (feeling of having an urge to vomit)
Rhinorrhoea (watery mucus discharge from the nose)
Chronic kidney disease

50-59:

Contusion (a type of hematoma of tissue in which capillaries)
Diarrhoea
Drug effect decreased
Drug ineffective
Haematochezia (passage of stools containing blood)
Liver disorder (liver diseases)
Menstruation irregular
Muscle spasms (muscle contraction)
Pain in extremity
Polyp

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Arthralgia (joint pain)
Infection
Injection site pain
Laryngitis (inflammation of the larynx)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 20 people, 48.78%
Constipation: 8 people, 19.51%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 8 people, 19.51%
High Blood Cholesterol: 8 people, 19.51%
Headache (pain in head): 7 people, 17.07%
Depression: 6 people, 14.63%
High Blood Pressure: 6 people, 14.63%
Infection: 5 people, 12.20%
Insomnia (sleeplessness): 5 people, 12.20%
Chest Pain: 5 people, 12.20%

* Approximation only. Some reports may have incomplete information.

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