Zantac and Nolvadex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zantac (ranitidine hydrochloride) and Nolvadex (tamoxifen citrate). Common drug interactions include pain among females and abdominal distension among males.

The phase IV clinical study analyzes what interactions people have when they take Zantac and Nolvadex. It is created by eHealthMe based on reports of 93 people who take the same drugs from the FDA, and is updated regularly.

What is Zantac?

Zantac has active ingredients of ranitidine hydrochloride. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 434,161 Zantac users. Check the latest studies of Zantac.

What is Nolvadex?

Nolvadex has active ingredients of tamoxifen citrate. It is often used in breast cancer. eHealthMe is studying from 5,506 Nolvadex users. Check the latest studies of Nolvadex.

On Jul, 18, 2026

93 people who take Zantac and Nolvadex together, and have interactions are studied.

What are the common drug interactions of Zantac and Nolvadex, by gender? *:

female:

Pain
Swelling face
Spinal osteoarthritis (joint cartilage loss in spine)
Pain in jaw
Exostosis (formation of new bone on the surface of a bone)
Oedema (fluid collection in tissue)
Oedema peripheral (superficial swelling)
Abdominal pain
Fall
Osteomyelitis (infection of bone)

male:

Abdominal distension
Abdominal pain
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Asthenia (weakness)
Asthma
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Atrioventricular block first degree (heart block first degree)
Back pain

What are the common drug interactions of Zantac and Nolvadex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Scar
Anxiety
Injury
Pain
Arthralgia (joint pain)
Back pain
Bone disorder
Cervical dysplasia (abnormal changes in the cells on the surface of the cervix)
Cervix carcinoma (cancer of cervix)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)

40-49:

Nausea (feeling of having an urge to vomit)
Vomiting
Alanine aminotransferase increased
Aspartate aminotransferase increased
Dental caries
Febrile neutropenia (fever with reduced white blood cells)
Leukopenia (less number of white blood cells in blood)
Myalgia (muscle pain)
Neutrophil count increased (excess than normal number of neutrophil a type of blood cell)
Periodontitis (inflammation of the tissue around the teeth)

50-59:

Diarrhoea
Febrile neutropenia (fever with reduced white blood cells)
Atypical femur fracture
Pseudarthrosis (bones that do not heal after fracture)
Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Anaemia (lack of blood)
Bronchopulmonary aspergillosis (lung disorder caused by aspergillus fungi)
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)

60+:

Osteomyelitis (infection of bone)
Back pain
Arrhythmia (irregular heartbeat)
Arthralgia (joint pain)
Chest pain
Depression
Intervertebral disc protrusion (spinal disc protrusion)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cataract (clouding of the lens inside the eye)
Injury

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 29 people, 31.18%
Breast Cancer Metastatic: 18 people, 19.35%
Metastatic Neoplasm (spreadable cancer tumour): 16 people, 17.20%
Sleep Apnea Syndrome: 12 people, 12.90%
Hypersensitivity: 12 people, 12.90%
Diabetes: 12 people, 12.90%
Pain: 11 people, 11.83%
Paget's Disease (disorder that involves abnormal bone destruction and regrowth, which results in deformity): 10 people, 10.75%
Osteoporosis (bones weak and more likely to break): 10 people, 10.75%

* Approximation only. Some reports may have incomplete information.

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