Sinemet cr and Digoxin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sinemet cr (carbidopa; levodopa) and Digoxin (digoxin). Common drug interactions include death among females and abnormal behaviour among males.

The phase IV clinical study analyzes what interactions people have when they take Sinemet cr and Digoxin. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Sinemet cr?

Sinemet cr has active ingredients of carbidopa; levodopa. It is often used in parkinson's disease. eHealthMe is studying from 2,852 Sinemet cr users. Check the latest studies of Sinemet cr.

What is Digoxin?

Digoxin has active ingredients of digoxin. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 93,740 Digoxin users. Check the latest studies of Digoxin.

On Jul, 06, 2026

38 people who take Sinemet cr and Digoxin together, and have interactions are studied.

Sinemet cr and Digoxin drug interactions.

What are the common drug interactions of Sinemet Cr and Digoxin, by gender? *:

female:

Death
Catatonia (unresponsive to external stimuli)
International normalised ratio increased
Tremor (trembling or shaking movements in one or more parts of your body)
Anaemia haemolytic autoimmune (a condition in which the immune system attacks the red blood cells, resulting in fewer of these oxygen-transporting cells)
Aphasia (damage to the parts of the brain that control language)
Cardiac disorder
Confusion
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Drug administration error

male:

Abnormal behaviour
Aggression
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Psychotic disorder
Constipation
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Hypotension (abnormally low blood pressure)
Miosis (constriction of the pupil of the eye, resulting from a normal response to an increase in light)
Paralysis

What are the common drug interactions of Sinemet Cr and Digoxin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Death
Catatonia (unresponsive to external stimuli)
Dyspnoea (difficult or laboured respiration)
Gait disturbance
Hallucination (an experience involving the perception of something not present)
Hepatomegaly (abnormal enlargement of the liver)
Hypotension (abnormally low blood pressure)
Lactic acidosis (low ph in body tissues)
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Miosis (constriction of the pupil of the eye, resulting from a normal response to an increase in light)

What are the existing conditions these people have? *

Ill-Defined Disorder: 3 people, 7.89%

* Approximation only. Some reports may have incomplete information.

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