Bactrim and Silvadene drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Bactrim (sulfamethoxazole; trimethoprim) and Silvadene (silver sulfadiazine). Common drug interactions include chest discomfort among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Bactrim and Silvadene. It is created by eHealthMe based on reports of 56 people who take the same drugs from the FDA, and is updated regularly.

What is Bactrim?

Bactrim has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 89,117 Bactrim users. Check the latest studies of Bactrim.

What is Silvadene?

Silvadene has active ingredients of silver sulfadiazine. eHealthMe is studying from 1,161 Silvadene users. Check the latest studies of Silvadene.

On Jul, 06, 2026

56 people who take Bactrim and Silvadene together, and have interactions are studied.

Bactrim and Silvadene drug interactions.

What are the common drug interactions of Bactrim and Silvadene, by gender? *:

female:

Chest discomfort
Chronic kidney disease
Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
Erythema (redness of the skin)
Fall
Hyperkalaemia (damage to or disease of the kidney)
Hypersensitivity
International normalised ratio increased
Malignant melanoma (skin cancer rises from melancytes)
Nausea (feeling of having an urge to vomit)

male:

Renal failure (kidney dysfunction)
Respiratory failure (inadequate gas exchange by the respiratory system)
Chronic kidney disease
Drug ineffective
Lung neoplasm malignant (cancer tumour of lung)
Abdominal pain
Anxiety
Decreased appetite
Drug dependence
Dyspnoea (difficult or laboured respiration)

What are the common drug interactions of Bactrim and Silvadene, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Application site irritation
Crying
Tremor (trembling or shaking movements in one or more parts of your body)
Wound complication
Wound haemorrhage (bleeding wound)

10-19:

Cough
Throat tightness
Urticaria (rash of round, red welts on the skin that itch intensely)

20-29:

Death

30-39:

Abdominal pain
Anxiety
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Emotional distress
General physical health deterioration (weak health status)
Injury
Pain
Thrombosis (formation of a blood clot inside a blood vessel)
Cytomegalovirus gastritis (virus infection of stomach)

40-49:

Faecal incontinence (a lack of control over passing stool)
Fall
Haematochezia (passage of stools containing blood)
Haematuria (presence of blood in urine)
Insomnia (sleeplessness)
Nausea (feeling of having an urge to vomit)
Nocturia (the need to get up in the night to urinate)
Pain
Renal colic (renal pain)
Thermal burn (burn by heat)

50-59:

Renal failure (kidney dysfunction)
Cardiac failure congestive
Dehydration (dryness resulting from the removal of water)
Respiratory failure (inadequate gas exchange by the respiratory system)
Sepsis (a severe blood infection that can lead to organ failure and death)
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Thrombocytopenia (decrease of platelets in blood)
Malignant neoplasm progression (cancer tumour came back)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Lung neoplasm malignant (cancer tumour of lung)

60+:

Breast cancer female
Diffuse large b-cell lymphoma stage i (cancer of b cells, a type of white blood cell- stage i)
Cardiac failure congestive
Cellulitis (infection under the skin)
Chronic kidney disease
Constipation
Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
Hyperkalaemia (damage to or disease of the kidney)
International normalised ratio increased
Malignant melanoma (skin cancer rises from melancytes)

What are the existing conditions these people have? *

Pain: 16 people, 28.57%
Nausea (feeling of having an urge to vomit): 13 people, 23.21%
Stress And Anxiety: 8 people, 14.29%
Neuropathy Peripheral (surface nerve damage): 8 people, 14.29%
Thrombocytopenia (decrease of platelets in blood): 8 people, 14.29%
Diarrhea: 8 people, 14.29%
High Blood Pressure: 6 people, 10.71%
Weight Decreased: 5 people, 8.93%
Fatigue (feeling of tiredness): 5 people, 8.93%
Anaemia (lack of blood): 5 people, 8.93%

* Approximation only. Some reports may have incomplete information.

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