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Methotrexate and Interleukin-2 receptor increased - a phase IV clinical study of FDA data

Summary:

Interleukin-2 receptor increased is reported as a side effect among people who take Methotrexate (methotrexate sodium), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Cyclosporine, and have Bone marrow conditioning regimen.

The phase IV clinical study analyzes which people have Interleukin-2 receptor increased when taking Methotrexate. It is created by eHealthMe based on reports of 599,650 people who have side effects when taking Methotrexate from the FDA, and is updated regularly.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,312 Methotrexate users. Check the latest studies of Methotrexate.

What is Interleukin-2 receptor increased?

Interleukin-2 receptor increased is found to be associated with 35 drugs and 99 conditions by eHealthMe. Check the latest studies of Interleukin-2 receptor increased.

On Jul, 06, 2026

599,650 people reported to have side effects when taking Methotrexate.
Among them, 26 people (0.0%) have Interleukin-2 receptor increased.

Could Methotrexate cause Interleukin-2 receptor increased?

Among these 26 people:

How long have people been on Methotrexate when they have Interleukin-2 receptor increased? *

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Interleukin-2 receptor increased when taking Methotrexate? *

  • female: 62.5 %
  • male: 37.5 %

What is the age of people who have Interleukin-2 receptor increased when taking Methotrexate? *

  • 0-1: 0.0 %
  • 2-9: 13.64 %
  • 10-19: 0.0 %
  • 20-29: 13.64 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 27.27 %
  • 60+: 45.45 %

What are other drugs people take besides Methotrexate? *

  1. Cortisone Acetate: 3 people, 11.54%
  2. Prednisolone: 3 people, 11.54%
  3. Cyclosporine: 3 people, 11.54%
  4. Actemra: 2 people, 7.69%
  5. Humira: 2 people, 7.69%
  6. Pyrimethamine: 2 people, 7.69%
  7. Cyclophosphamide: 1 person, 3.85%
  8. Dexamethasone: 1 person, 3.85%
  9. Dipyrone: 1 person, 3.85%
  10. Enbrel: 1 person, 3.85%

What are other side effects people have besides Interleukin-2 receptor increased? *

  1. Fever: 11 people, 42.31%
  2. Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets): 9 people, 34.62%
  3. Epstein-Barr Virus Infection: 9 people, 34.62%
  4. Lymphoproliferative Disorder (a medical condition in which the immune system makes too many white blood cells): 6 people, 23.08%
  5. Serum Ferritin Increased: 6 people, 23.08%
  6. Headache (pain in head): 6 people, 23.08%
  7. C-Reactive Protein Increased: 5 people, 19.23%
  8. Malaise (a feeling of general discomfort or uneasiness): 5 people, 19.23%
  9. Hepatomegaly (abnormal enlargement of the liver): 5 people, 19.23%
  10. Chills (felling of cold): 4 people, 15.38%

What are the existing conditions these people have? *

  1. Cerebral Toxoplasmosis (parasitic disease of brain caused by the protozoan toxoplasma gondii): 4 people, 15.38%
  2. Bone Marrow Conditioning Regimen: 4 people, 15.38%
  3. Sarcoidosis (an inflammatory disease that affects multiple organs in the body, but mostly the lungs and lymph glands): 3 people, 11.54%
  4. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 3 people, 11.54%
  5. Psoriasis (immune-mediated disease that affects the skin): 2 people, 7.69%
  6. Juvenile Rheumatoid Arthritis (joint inflammation in children due to systemic disease): 2 people, 7.69%
  7. Blood Immunoglobulin G Decreased: 2 people, 7.69%
  8. Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 2 people, 7.69%
  9. Plasmablastic Lymphoma (aggressive b-cell cancer occurring mainly in the jaws and oral cavity): 1 person, 3.85%
  10. Lymphoproliferative Disorder (a medical condition in which the immune system makes too many white blood cells): 1 person, 3.85%

* Approximation only. Some reports may have incomplete information.

Do you take Methotrexate and have Interleukin-2 receptor increased?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Methotrexate:

Interleukin-2 receptor increased treatments and more:

How severe was Interleukin-2 receptor increased and when was it recovered:

Expand to all the drugs that have ingredients of methotrexate sodium:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Methotrexate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Interleukin-2 receptor increased:

Browse all the conditions that are associated with Interleukin-2 receptor increased:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on methotrexate sodium (the active ingredients of Methotrexate) and Methotrexate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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