Sinemet and Divalproex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sinemet (carbidopa; levodopa) and Divalproex (divalproex sodium). Common drug interactions include intervertebral disc degeneration among females and balance disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Sinemet and Divalproex. It is created by eHealthMe based on reports of 64 people who take the same drugs from the FDA, and is updated regularly.

What is Sinemet?

Sinemet has active ingredients of carbidopa; levodopa. It is often used in parkinson's disease. eHealthMe is studying from 29,601 Sinemet users. Check the latest studies of Sinemet.

What is Divalproex?

Divalproex has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 14,063 Divalproex users. Check the latest studies of Divalproex.

On Jul, 09, 2026

64 people who take Sinemet and Divalproex together, and have interactions are studied.

Sinemet and Divalproex drug interactions.

What are the common drug interactions of Sinemet and Divalproex, by gender? *:

female:

Intervertebral disc degeneration (spinal disc degeneration)
Intervertebral disc displacement
Multiple system atrophy (degeneration of nerve cells in specific areas of the brain)
Neck pain
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Spinal osteoarthritis (joint cartilage loss in spine)
Vertigo
Vision blurred
Confusional state
Drug ineffective

male:

Balance disorder
Tremor (trembling or shaking movements in one or more parts of your body)
Dizziness
Drug hypersensitivity
Headache (pain in head)
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Microangiopathy (disease of the capillaries (very small blood vessels), in which the capillary walls become so thick and weak that they bleed, leak protein)
Neoplasm malignant (cancer tumour)
Vision blurred
Death

What are the common drug interactions of Sinemet and Divalproex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Anxiety
Chest pain

50-59:

Multiple system atrophy (degeneration of nerve cells in specific areas of the brain)
Muscular weakness (muscle weakness)
Neck pain
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Spinal osteoarthritis (joint cartilage loss in spine)
Vertigo
Vision blurred
Pyrexia (fever)
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Akinesia (loss of control of voluntary muscle movements)

60+:

Fall
Muscular weakness (muscle weakness)
Cerebellar atrophy (degeneration of the section of the brain responsible for balance, voluntary muscle movements)
Cerebral arteriosclerosis (thickening and hardening of the walls of the arteries in the brain)
Confusional state
Drug hypersensitivity
Hallucination (an experience involving the perception of something not present)
Headache (pain in head)
Memory impairment
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)

What are the existing conditions these people have? *

Seizures (abnormal excessive or synchronous neuronal activity in the brain): 9 people, 14.06%
Hallucinations (sensations that appear real but are created by your mind): 9 people, 14.06%
Delusion (a false belief or opinion): 9 people, 14.06%
Pain: 7 people, 10.94%
Constipation: 7 people, 10.94%
Stress And Anxiety: 6 people, 9.38%
Insomnia (sleeplessness): 6 people, 9.38%
Sleep Disorder: 5 people, 7.81%
Dizziness: 5 people, 7.81%
Depression: 5 people, 7.81%

* Approximation only. Some reports may have incomplete information.

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