Sinemet and Estradiol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sinemet (carbidopa; levodopa) and Estradiol (estradiol). Common drug interactions include urinary tract infection among females.

The phase IV clinical study analyzes what interactions people have when they take Sinemet and Estradiol. It is created by eHealthMe based on reports of 53 people who take the same drugs from the FDA, and is updated regularly.

What is Sinemet?

Sinemet has active ingredients of carbidopa; levodopa. It is often used in parkinson's disease. eHealthMe is studying from 29,601 Sinemet users. Check the latest studies of Sinemet.

What is Estradiol?

Estradiol has active ingredients of estradiol. It is often used in menopause. eHealthMe is studying from 18,986 Estradiol users. Check the latest studies of Estradiol.

On Jul, 20, 2026

53 people who take Sinemet and Estradiol together, and have interactions are studied.

Sinemet and Estradiol drug interactions.

What are the common drug interactions of Sinemet and Estradiol, by gender? *:

female:

Urinary tract infection
Colitis ischaemic (due to infection of intestine impaired blood supply to colon)
Nausea (feeling of having an urge to vomit)
Peripheral swelling
Sinusitis (inflammation of sinus)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Delusion (a false belief or opinion)
Erythema (redness of the skin)
Fall

male:

n/a

What are the common drug interactions of Sinemet and Estradiol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Colitis ischaemic (due to infection of intestine impaired blood supply to colon)
Haemorrhage (bleeding)
Haematochezia (passage of stools containing blood)

40-49:

Cellulitis (infection under the skin)
Cellulitis gangrenous (localized inflammation of the soft or connective tissue with considerable mass of body tissue dies (necrosis))
Gangrene (body tissue dies)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Perineal abscess
Sepsis (a severe blood infection that can lead to organ failure and death)
Urinary tract infection
Vulval abscess
Vulval cellulitis (inflammation of skin around vagina)
Vulvitis (inflammation of the vulva)

50-59:

Colitis ischaemic (due to infection of intestine impaired blood supply to colon)
Lower gastrointestinal haemorrhage (bleeding in the large intestine, rectum, or anus is called lower gi bleeding)
Blood urea increased
Hyperaemia (increase of blood flow to different tissues in the body)
Irritable bowel syndrome
Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest)
Oedema mucosal (swelling of mucous membrane)
Axillary mass
Mucous membrane disorder (disease of mucous membrane)
Night sweats (sweating in night)

60+:

Dehydration (dryness resulting from the removal of water)
Constipation
Abdominal distension
Abdominal pain upper
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Blood glucose increased
Blood pressure increased
Burning sensation
Colitis ischaemic (due to infection of intestine impaired blood supply to colon)
Cystitis (inflammation of the wall of the bladder)

What are the existing conditions these people have? *

Pain: 15 people, 28.30%
Immunodeficiency Common Variable: 6 people, 11.32%
Hallucinations (sensations that appear real but are created by your mind): 5 people, 9.43%
Delusion (a false belief or opinion): 5 people, 9.43%
Urine Analysis Abnormal: 4 people, 7.55%
Muscle Aches (muscle pain): 4 people, 7.55%
Lewis-Sumner Syndrome (a dysimmune multifocal demyelinating sensorimotor neuropathy): 4 people, 7.55%
Hypocitraturia (low amount of citrate in the urine, is an important risk factor for kidney stone formation): 4 people, 7.55%
Chronic Inflammatory Demyelinating Polyradiculoneuropathy (long lasting infection of nerves outside brain and spinal cord): 4 people, 7.55%

* Approximation only. Some reports may have incomplete information.

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